SYST-28 FUNCTIONAL MAPPING REVEALS WIDESPREAD REMODELLING AND A NOVEL TARGETABLE PTP4A2-ROBO1 SIGNALING AXIS AT GLIOBLASTOMA RECURRENCE

Resistance to genotoxic therapies and tumor recurrence are hallmarks of glioblastoma (GBM), an aggressive brain tumor. Here, we explore the functional drivers of post-treatment recurrent GBM. By conducting genome-wide CRISPR-Cas9 screens in patient-derived GBM models, we uncover distinct genetic dep...

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Detalles Bibliográficos
Autores principales: Chokshi, Chirayu, Shaikh, Vaseem, Tieu, David, Brakel, Benjamin, Brown, Kevin, chan, Katherine, rossotti, Martin, Maich, William, Venugopal, Chitra, Anand, Alisha, Lazo, John, Kislinger, Thomas, Lu, Jian, Provias, John, Henry, Kevin, Moffat, Jason, Singh, Sheila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Systemic Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402377/
http://dx.doi.org/10.1093/noajnl/vdad070.130

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