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BSBM-21 MACHINE LEARNING IDENTIFIES EXPERIMENTAL BRAIN METASTASIS SUBTYPES BASED ON THEIR INFLUENCE ON NEURAL CIRCUITS
A high percentage of patients with brain metastases frequently develop neurocognitive symptoms, however understanding how brain metastasis co-opt the function of neuronal circuits beyond a mass effect remains unknown. We report a comprehensive multidimensional modelling of brain functional analysis...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402387/ http://dx.doi.org/10.1093/noajnl/vdad070.017 |
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author | Masmudi-Martin, Mariam Sanchez-Aguilera, Alberto Navas-Olive, Andrea Baena, Patricia Hernández-Oliver, Carolina Martínez, Sonia Lafarga, Miguel Lin, Michael Z de la Prida, Liset Menendez Valiente, Manuel |
author_facet | Masmudi-Martin, Mariam Sanchez-Aguilera, Alberto Navas-Olive, Andrea Baena, Patricia Hernández-Oliver, Carolina Martínez, Sonia Lafarga, Miguel Lin, Michael Z de la Prida, Liset Menendez Valiente, Manuel |
author_sort | Masmudi-Martin, Mariam |
collection | PubMed |
description | A high percentage of patients with brain metastases frequently develop neurocognitive symptoms, however understanding how brain metastasis co-opt the function of neuronal circuits beyond a mass effect remains unknown. We report a comprehensive multidimensional modelling of brain functional analysis in the context of brain metastasis. By testing different pre-clinical models of brain metastasis from various primary sources and oncogenic profiles we dissociated the heterogeneous impact on brain function that we detected from the homogeneous inter-model tumor size or glial response. In contrast we report a potential underlying molecular program responsible for impairing neuronal crosstalk in a model-specific manner. Additionally, measurement of various brain activity readouts matched with machine learning strategies confirmed model-specific alterations that could help to predict the presence and subtype of metastasis. We envision that our findings not only increase our knowledge on the molecular basis of neurocognitive impairment associated with brain metastases but they are also the first step towards new therapeutic strategies to prevent or stop the decline in quality of life associated with these symptoms. In addition, our computational findings exploiting electrophysiological profiles suggest the possibility to exploit them as novel biomarkers. |
format | Online Article Text |
id | pubmed-10402387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-104023872023-08-05 BSBM-21 MACHINE LEARNING IDENTIFIES EXPERIMENTAL BRAIN METASTASIS SUBTYPES BASED ON THEIR INFLUENCE ON NEURAL CIRCUITS Masmudi-Martin, Mariam Sanchez-Aguilera, Alberto Navas-Olive, Andrea Baena, Patricia Hernández-Oliver, Carolina Martínez, Sonia Lafarga, Miguel Lin, Michael Z de la Prida, Liset Menendez Valiente, Manuel Neurooncol Adv Final Category: Basic Science of Brain Metastases A high percentage of patients with brain metastases frequently develop neurocognitive symptoms, however understanding how brain metastasis co-opt the function of neuronal circuits beyond a mass effect remains unknown. We report a comprehensive multidimensional modelling of brain functional analysis in the context of brain metastasis. By testing different pre-clinical models of brain metastasis from various primary sources and oncogenic profiles we dissociated the heterogeneous impact on brain function that we detected from the homogeneous inter-model tumor size or glial response. In contrast we report a potential underlying molecular program responsible for impairing neuronal crosstalk in a model-specific manner. Additionally, measurement of various brain activity readouts matched with machine learning strategies confirmed model-specific alterations that could help to predict the presence and subtype of metastasis. We envision that our findings not only increase our knowledge on the molecular basis of neurocognitive impairment associated with brain metastases but they are also the first step towards new therapeutic strategies to prevent or stop the decline in quality of life associated with these symptoms. In addition, our computational findings exploiting electrophysiological profiles suggest the possibility to exploit them as novel biomarkers. Oxford University Press 2023-08-04 /pmc/articles/PMC10402387/ http://dx.doi.org/10.1093/noajnl/vdad070.017 Text en © The Author(s) 2023. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Final Category: Basic Science of Brain Metastases Masmudi-Martin, Mariam Sanchez-Aguilera, Alberto Navas-Olive, Andrea Baena, Patricia Hernández-Oliver, Carolina Martínez, Sonia Lafarga, Miguel Lin, Michael Z de la Prida, Liset Menendez Valiente, Manuel BSBM-21 MACHINE LEARNING IDENTIFIES EXPERIMENTAL BRAIN METASTASIS SUBTYPES BASED ON THEIR INFLUENCE ON NEURAL CIRCUITS |
title | BSBM-21 MACHINE LEARNING IDENTIFIES EXPERIMENTAL BRAIN METASTASIS SUBTYPES BASED ON THEIR INFLUENCE ON NEURAL CIRCUITS |
title_full | BSBM-21 MACHINE LEARNING IDENTIFIES EXPERIMENTAL BRAIN METASTASIS SUBTYPES BASED ON THEIR INFLUENCE ON NEURAL CIRCUITS |
title_fullStr | BSBM-21 MACHINE LEARNING IDENTIFIES EXPERIMENTAL BRAIN METASTASIS SUBTYPES BASED ON THEIR INFLUENCE ON NEURAL CIRCUITS |
title_full_unstemmed | BSBM-21 MACHINE LEARNING IDENTIFIES EXPERIMENTAL BRAIN METASTASIS SUBTYPES BASED ON THEIR INFLUENCE ON NEURAL CIRCUITS |
title_short | BSBM-21 MACHINE LEARNING IDENTIFIES EXPERIMENTAL BRAIN METASTASIS SUBTYPES BASED ON THEIR INFLUENCE ON NEURAL CIRCUITS |
title_sort | bsbm-21 machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits |
topic | Final Category: Basic Science of Brain Metastases |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402387/ http://dx.doi.org/10.1093/noajnl/vdad070.017 |
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