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SYST-13 AAV VECTOR ENCODING FC MODIFIED HER2 ANTIBODIES REDUCES TUMOR BURDEN WITH MINIMIZED PERIPHERAL EXPOSURE IN MODELS OF BREAST CANCER BRAIN METASTASIS

We engineered a HER2 Ab that inhibited HER2+ breast cancer cell growth in vitro and led to a profound increase in Ab-dependent CD16A receptor stimulation relative to trastuzumab, the standard of care. Blood-brain barrier penetrant AAV vectors were administered intravenously to mice orthotopically en...

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Detalles Bibliográficos
Autores principales:	Laks, Dan, Ren, Xiaoqin, Shah, Ishan, Thompson, Jeffrey, Clement, Joe, Moyer, Tyler, Nonnenmacher, Mathieu, Carter, Todd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Final Category: Systemic Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402399/ http://dx.doi.org/10.1093/noajnl/vdad070.117

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