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Fabrication of bioactive nanocomposites from chitosan, cress mucilage, and selenium nanoparticles with powerful antibacterial and anticancerous actions
Natural bioactive alternatives are the utmost requests from researchers to provide biosafe and effectual health-guarding agents. The biopolymers chitosan nanoparticles (NCT), mucilage of cress seed (GCm; Lepidium sativum), and GCm-mediated selenium nanoparticles (GCm/SeNPs) were innovatively employe...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402636/ https://www.ncbi.nlm.nih.gov/pubmed/37547689 http://dx.doi.org/10.3389/fmicb.2023.1210780 |
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author | El-Sherbiny, Mohsen M. Orif, Mohamed I. El-Hefnawy, Mohamed E. Alhayyani, Sultan Al-Goul, Soha T. Elekhtiar, Rawan S. Mahrous, Hoda Tayel, Ahmed A. |
author_facet | El-Sherbiny, Mohsen M. Orif, Mohamed I. El-Hefnawy, Mohamed E. Alhayyani, Sultan Al-Goul, Soha T. Elekhtiar, Rawan S. Mahrous, Hoda Tayel, Ahmed A. |
author_sort | El-Sherbiny, Mohsen M. |
collection | PubMed |
description | Natural bioactive alternatives are the utmost requests from researchers to provide biosafe and effectual health-guarding agents. The biopolymers chitosan nanoparticles (NCT), mucilage of cress seed (GCm; Lepidium sativum), and GCm-mediated selenium nanoparticles (GCm/SeNPs) were innovatively employed for fabricating novel bioactive natural nanocomposites (NCs) with elevated bioactivities as bactericidal (against Salmonella typhimurium and Staphylococcus aureus) and anticancer (against CaCo-2 and HeLa cells). The SeNPs were successfully generated with GCm, and different NCs formulations were fabricated from NCT:GCm/SeNPs amalgam ratios including T1, T2, and T3 with 2:1, 1:1, and 1:2 ratios, respectively. The infrared analysis of synthesized molecules appointed apparent physical interactions among interacted molecules. The average particles’ sizes and charges of molecules/NCs were (12.7, 316.4, 252.8, and 127.3 nm) and (−6.9, +38.7, +26.2, and −25.8 mV) for SeNPs, T1, T2, and T3, respectively. The biocidal assessment of NCs indicated that T1 was the strongest antibacterial formulation, whereas T3 was the superior anticancer amalgam. These NCs formulations could exceed the biocidal potentialities of standard biocides. T1-NC could cause severe destructions/deformations in challenged S. typhimurium within 9 h, whereas T3-NCs induced apparent fluorescent apoptosis signs in treated HeLa cells. The prospective applications innovatively designed biocidal natural NCs that are recommended for controlling pathogenic bacteria and fighting cancerous cells. |
format | Online Article Text |
id | pubmed-10402636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104026362023-08-05 Fabrication of bioactive nanocomposites from chitosan, cress mucilage, and selenium nanoparticles with powerful antibacterial and anticancerous actions El-Sherbiny, Mohsen M. Orif, Mohamed I. El-Hefnawy, Mohamed E. Alhayyani, Sultan Al-Goul, Soha T. Elekhtiar, Rawan S. Mahrous, Hoda Tayel, Ahmed A. Front Microbiol Microbiology Natural bioactive alternatives are the utmost requests from researchers to provide biosafe and effectual health-guarding agents. The biopolymers chitosan nanoparticles (NCT), mucilage of cress seed (GCm; Lepidium sativum), and GCm-mediated selenium nanoparticles (GCm/SeNPs) were innovatively employed for fabricating novel bioactive natural nanocomposites (NCs) with elevated bioactivities as bactericidal (against Salmonella typhimurium and Staphylococcus aureus) and anticancer (against CaCo-2 and HeLa cells). The SeNPs were successfully generated with GCm, and different NCs formulations were fabricated from NCT:GCm/SeNPs amalgam ratios including T1, T2, and T3 with 2:1, 1:1, and 1:2 ratios, respectively. The infrared analysis of synthesized molecules appointed apparent physical interactions among interacted molecules. The average particles’ sizes and charges of molecules/NCs were (12.7, 316.4, 252.8, and 127.3 nm) and (−6.9, +38.7, +26.2, and −25.8 mV) for SeNPs, T1, T2, and T3, respectively. The biocidal assessment of NCs indicated that T1 was the strongest antibacterial formulation, whereas T3 was the superior anticancer amalgam. These NCs formulations could exceed the biocidal potentialities of standard biocides. T1-NC could cause severe destructions/deformations in challenged S. typhimurium within 9 h, whereas T3-NCs induced apparent fluorescent apoptosis signs in treated HeLa cells. The prospective applications innovatively designed biocidal natural NCs that are recommended for controlling pathogenic bacteria and fighting cancerous cells. Frontiers Media S.A. 2023-07-21 /pmc/articles/PMC10402636/ /pubmed/37547689 http://dx.doi.org/10.3389/fmicb.2023.1210780 Text en Copyright © 2023 El-Sherbiny, Orif, El-Hefnawy, Alhayyani, Al-Goul, Elekhtiar, Mahrous and Tayel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology El-Sherbiny, Mohsen M. Orif, Mohamed I. El-Hefnawy, Mohamed E. Alhayyani, Sultan Al-Goul, Soha T. Elekhtiar, Rawan S. Mahrous, Hoda Tayel, Ahmed A. Fabrication of bioactive nanocomposites from chitosan, cress mucilage, and selenium nanoparticles with powerful antibacterial and anticancerous actions |
title | Fabrication of bioactive nanocomposites from chitosan, cress mucilage, and selenium nanoparticles with powerful antibacterial and anticancerous actions |
title_full | Fabrication of bioactive nanocomposites from chitosan, cress mucilage, and selenium nanoparticles with powerful antibacterial and anticancerous actions |
title_fullStr | Fabrication of bioactive nanocomposites from chitosan, cress mucilage, and selenium nanoparticles with powerful antibacterial and anticancerous actions |
title_full_unstemmed | Fabrication of bioactive nanocomposites from chitosan, cress mucilage, and selenium nanoparticles with powerful antibacterial and anticancerous actions |
title_short | Fabrication of bioactive nanocomposites from chitosan, cress mucilage, and selenium nanoparticles with powerful antibacterial and anticancerous actions |
title_sort | fabrication of bioactive nanocomposites from chitosan, cress mucilage, and selenium nanoparticles with powerful antibacterial and anticancerous actions |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402636/ https://www.ncbi.nlm.nih.gov/pubmed/37547689 http://dx.doi.org/10.3389/fmicb.2023.1210780 |
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