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mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease

BACKGROUND: Chronic kidney disease (CKD) is a complex syndrome with high morbidity and slow progression. Early stages of CKD are asymptomatic and lack of awareness at this stage allows CKD to progress through to advanced stages. Early detection of CKD is critical for the early intervention and progn...

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Autores principales: Wang, Yue, Ju, Ye, An, Qi, Lin, Liangjie, Liu, Ai Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402729/
https://www.ncbi.nlm.nih.gov/pubmed/37547308
http://dx.doi.org/10.3389/fendo.2023.1187042
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author Wang, Yue
Ju, Ye
An, Qi
Lin, Liangjie
Liu, Ai Lian
author_facet Wang, Yue
Ju, Ye
An, Qi
Lin, Liangjie
Liu, Ai Lian
author_sort Wang, Yue
collection PubMed
description BACKGROUND: Chronic kidney disease (CKD) is a complex syndrome with high morbidity and slow progression. Early stages of CKD are asymptomatic and lack of awareness at this stage allows CKD to progress through to advanced stages. Early detection of CKD is critical for the early intervention and prognosis improvement. PURPOSE: To assess the capability of mDIXON-Quant imaging to detect early CKD and evaluate the degree of renal damage in patients with CKD. STUDY TYPE: Retrospective. POPULATION: 35 patients with CKD: 18 cases were classifified as the mild renal damage group (group A) and 17 cases were classifified as the moderate to severe renal damage group (group B). 22 healthy volunteers (group C). FIELD STRENGTH/SEQUENCE: A 3.0 T/T(1)WI, T(2)WI and mDIXON-Quant sequences. ASSESSMENT: Transverse relaxation rate (R2*) values and fat fraction (FF) values derived from the mDIXON-Quant were calculated and compared among the three groups. STATISTICAL TESTS: The intra-class correlation (ICC) test; Chi-square test or Fisher’s exact test; Shapiro-Wilk test; Kruskal Wallis test with adjustments for multiplicity (Bonferroni test); Area under the receiver operating characteristic (ROC) curve (AUC). The significance threshold was set at P < 0.05. RESULTS: Cortex FF values and cortex R2* values were significantly different among the three groups (P=0.028, <0.001), while medulla R2* values and medulla FF values were not (P=0.110, 0.139). Cortex FF values of group B was significantly higher than that of group A (Bonferroni adjusted P = 0.027). Cortex R2* values of group A and group B were both significantly higher than that of group C (Bonferroni adjusted P = 0.012, 0.001). The AUC of cortex FF values in distinguishing group A and group B was 0.766. The diagnostic efficiency of cortex R2* values in distinguishing group A vs. group C and group B vs. group C were 0.788 and 0.829. CONCLUSION: The mDIXON-Quant imaging had a potential clinical value in early diagnosis of CKD and assessing the degree of renal damage in CKD patients.
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spelling pubmed-104027292023-08-05 mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease Wang, Yue Ju, Ye An, Qi Lin, Liangjie Liu, Ai Lian Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Chronic kidney disease (CKD) is a complex syndrome with high morbidity and slow progression. Early stages of CKD are asymptomatic and lack of awareness at this stage allows CKD to progress through to advanced stages. Early detection of CKD is critical for the early intervention and prognosis improvement. PURPOSE: To assess the capability of mDIXON-Quant imaging to detect early CKD and evaluate the degree of renal damage in patients with CKD. STUDY TYPE: Retrospective. POPULATION: 35 patients with CKD: 18 cases were classifified as the mild renal damage group (group A) and 17 cases were classifified as the moderate to severe renal damage group (group B). 22 healthy volunteers (group C). FIELD STRENGTH/SEQUENCE: A 3.0 T/T(1)WI, T(2)WI and mDIXON-Quant sequences. ASSESSMENT: Transverse relaxation rate (R2*) values and fat fraction (FF) values derived from the mDIXON-Quant were calculated and compared among the three groups. STATISTICAL TESTS: The intra-class correlation (ICC) test; Chi-square test or Fisher’s exact test; Shapiro-Wilk test; Kruskal Wallis test with adjustments for multiplicity (Bonferroni test); Area under the receiver operating characteristic (ROC) curve (AUC). The significance threshold was set at P < 0.05. RESULTS: Cortex FF values and cortex R2* values were significantly different among the three groups (P=0.028, <0.001), while medulla R2* values and medulla FF values were not (P=0.110, 0.139). Cortex FF values of group B was significantly higher than that of group A (Bonferroni adjusted P = 0.027). Cortex R2* values of group A and group B were both significantly higher than that of group C (Bonferroni adjusted P = 0.012, 0.001). The AUC of cortex FF values in distinguishing group A and group B was 0.766. The diagnostic efficiency of cortex R2* values in distinguishing group A vs. group C and group B vs. group C were 0.788 and 0.829. CONCLUSION: The mDIXON-Quant imaging had a potential clinical value in early diagnosis of CKD and assessing the degree of renal damage in CKD patients. Frontiers Media S.A. 2023-07-21 /pmc/articles/PMC10402729/ /pubmed/37547308 http://dx.doi.org/10.3389/fendo.2023.1187042 Text en Copyright © 2023 Wang, Ju, An, Lin and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wang, Yue
Ju, Ye
An, Qi
Lin, Liangjie
Liu, Ai Lian
mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease
title mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease
title_full mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease
title_fullStr mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease
title_full_unstemmed mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease
title_short mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease
title_sort mdixon-quant for differentiation of renal damage degree in patients with chronic kidney disease
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402729/
https://www.ncbi.nlm.nih.gov/pubmed/37547308
http://dx.doi.org/10.3389/fendo.2023.1187042
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