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Structural diversity and biological role of the 5’ untranslated regions of picornavirus
The genomic arrangement of most picornavirus of the Picornaviridae family shares a similar monocistronic genomic pattern and a defining organizational feature. A defining feature of picornavirus is the presence of evolutionarily conserved and highly-structured RNA elements in untranslated regions (U...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402851/ https://www.ncbi.nlm.nih.gov/pubmed/37534989 http://dx.doi.org/10.1080/15476286.2023.2240992 |
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author | Peng, Tingyu Yang, Fayu Yang, Fan Cao, Weijun Zheng, Haixue Zhu, Zixiang |
author_facet | Peng, Tingyu Yang, Fayu Yang, Fan Cao, Weijun Zheng, Haixue Zhu, Zixiang |
author_sort | Peng, Tingyu |
collection | PubMed |
description | The genomic arrangement of most picornavirus of the Picornaviridae family shares a similar monocistronic genomic pattern and a defining organizational feature. A defining feature of picornavirus is the presence of evolutionarily conserved and highly-structured RNA elements in untranslated regions (UTRs) at the genome’ 5’and 3’ ends, essential for viral replication and translation. Given the diversity and complexity of RNA structure and the limitations of molecular biology techniques, the functional characterization and biological significance of UTRs remain to be fully elucidated, especially for 5’ UTR. Here, we summarize the current knowledge of the 5’ UTR of picornavirus. This review focuses on the structural characterization and the biological function of the RNA secondary and tertiary structures in the 5’ UTR of picornavirus. Understanding the role of the 5’ UTR of picornavirus can provide a deep insight into the viral replication cycle and pathogenic mechanisms. |
format | Online Article Text |
id | pubmed-10402851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-104028512023-08-05 Structural diversity and biological role of the 5’ untranslated regions of picornavirus Peng, Tingyu Yang, Fayu Yang, Fan Cao, Weijun Zheng, Haixue Zhu, Zixiang RNA Biol Review The genomic arrangement of most picornavirus of the Picornaviridae family shares a similar monocistronic genomic pattern and a defining organizational feature. A defining feature of picornavirus is the presence of evolutionarily conserved and highly-structured RNA elements in untranslated regions (UTRs) at the genome’ 5’and 3’ ends, essential for viral replication and translation. Given the diversity and complexity of RNA structure and the limitations of molecular biology techniques, the functional characterization and biological significance of UTRs remain to be fully elucidated, especially for 5’ UTR. Here, we summarize the current knowledge of the 5’ UTR of picornavirus. This review focuses on the structural characterization and the biological function of the RNA secondary and tertiary structures in the 5’ UTR of picornavirus. Understanding the role of the 5’ UTR of picornavirus can provide a deep insight into the viral replication cycle and pathogenic mechanisms. Taylor & Francis 2023-08-03 /pmc/articles/PMC10402851/ /pubmed/37534989 http://dx.doi.org/10.1080/15476286.2023.2240992 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
spellingShingle | Review Peng, Tingyu Yang, Fayu Yang, Fan Cao, Weijun Zheng, Haixue Zhu, Zixiang Structural diversity and biological role of the 5’ untranslated regions of picornavirus |
title | Structural diversity and biological role of the 5’ untranslated regions of picornavirus |
title_full | Structural diversity and biological role of the 5’ untranslated regions of picornavirus |
title_fullStr | Structural diversity and biological role of the 5’ untranslated regions of picornavirus |
title_full_unstemmed | Structural diversity and biological role of the 5’ untranslated regions of picornavirus |
title_short | Structural diversity and biological role of the 5’ untranslated regions of picornavirus |
title_sort | structural diversity and biological role of the 5’ untranslated regions of picornavirus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402851/ https://www.ncbi.nlm.nih.gov/pubmed/37534989 http://dx.doi.org/10.1080/15476286.2023.2240992 |
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