PSGL-1 attenuates early TCR signaling to suppress CD8(+) T cell progenitor differentiation and elicit terminal CD8(+) T cell exhaustion

PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism of action. Here, we show that PSGL-1 acts upstream of PD-1 and requires co-ligation with the T cell receptor (TCR) to attenuate activation of mouse and human CD8(+) T cells and drive...

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Detalles Bibliográficos
Autores principales: Hope, Jennifer L., Otero, Dennis C., Bae, Eun-Ah, Stairiker, Christopher J., Palete, Ashley B., Faso, Hannah A., Lin, Michelle, Henriquez, Monique L., Roy, Sreeja, Seo, Hyungseok, Lei, Xue, Wang, Eric S., Chow, Savio, Tinoco, Roberto, Daniels, Gregory A., Yip, Kevin, Campos, Alexandre Rosa, Yin, Jun, Adams, Peter D., Rao, Anjana, Bradley, Linda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403047/
https://www.ncbi.nlm.nih.gov/pubmed/37115668
http://dx.doi.org/10.1016/j.celrep.2023.112436

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