Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis

The cytoplasmic aggregation of TAR DNA binding protein-43 (TDP-43), also known as TDP-43 pathology, is the pathological hallmark of amyotrophic lateral sclerosis (ALS). However, the mechanism underlying TDP-43 cytoplasmic mislocalization and subsequent aggregation remains unclear. Here, we show that...

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Detalles Bibliográficos
Autores principales: Oiwa, Kotaro, Watanabe, Seiji, Onodera, Kazunari, Iguchi, Yohei, Kinoshita, Yukako, Komine, Okiru, Sobue, Akira, Okada, Yohei, Katsuno, Masahisa, Yamanaka, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403219/
https://www.ncbi.nlm.nih.gov/pubmed/37540751
http://dx.doi.org/10.1126/sciadv.adf6895

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