Multiomics analyses reveal DARS1-AS1/YBX1–controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance

The glioblastoma (GBM) stem cell–like cells (GSCs) are critical for tumorigenesis/therapeutic resistance of GBM. Mounting evidence supports tumor-promoting function of long noncoding RNAs (lncRNAs), but their role in GSCs remains poorly understood. By combining CRISPRi screen with orthogonal multiom...

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Detalles Bibliográficos
Autores principales: Zheng, Caishang, Wei, Yanjun, Zhang, Qiang, Sun, Ming, Wang, Yunfei, Hou, Jiakai, Zhang, Peng, Lv, Xiangdong, Su, Dan, Jiang, Yujie, Gumin, Joy, Sahni, Nidhi, Hu, Baoli, Wang, Wenyi, Chen, Xi, McGrail, Daniel J., Zhang, Chaolin, Huang, Suyun, Xu, Han, Chen, Junjie, Lang, Frederick F., Hu, Jian, Chen, Yiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403220/
https://www.ncbi.nlm.nih.gov/pubmed/37540752
http://dx.doi.org/10.1126/sciadv.adf3984

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