Cargando…

Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression

In osteoarthritis (OA), a disease characterized by progressive articular cartilage degradation and calcification, the articular chondrocyte phenotype changes and this correlates with actin cytoskeleton alterations suggesting that it regulates gene expression essential for proper phenotype. This stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chan, Byron, Glogauer, Michael, Wang, Yongqiang, Wrana, Jeffrey, Chan, Kin, Beier, Frank, Bali, Supinder, Hinz, Boris, Parreno, Justin, Ashraf, Sajjad, Kandel, Rita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403223/ https://www.ncbi.nlm.nih.gov/pubmed/37540756 http://dx.doi.org/10.1126/sciadv.adf1130

Ejemplares similares

The Actin Binding Protein Adseverin Regulates Osteoclastogenesis
por: Hassanpour, Siavash, et al.
Publicado: (2014)

Deletion of Adseverin in Osteoclasts Affects Cell Structure But Not Bone Metabolism
por: Cao, Yixuan, et al.
Publicado: (2017)

Augmented ERAD (ER-associated degradation) activity in chondrocytes is necessary for cartilage development and maintenance
por: Sim, Hyo Jung, et al.
Publicado: (2022)

Partitioning of ribonucleoprotein complexes from the cellular actin cortex
por: Angert, Isaac, et al.
Publicado: (2022)

The membrane-actin linker ezrin acts as a sliding anchor
por: Korkmazhan, Elgin, et al.
Publicado: (2022)

Actin limits egg aneuploidies associated with female reproductive aging
por: Dunkley, Sam, et al.
Publicado: (2023)

Phase separation of an actin nucleator by junctional microtubules regulates epithelial function
por: Tsukita, Kazuto, et al.
Publicado: (2023)

Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia
por: Gong, Rui, et al.
Publicado: (2022)

Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in mice
por: Jouan, Yohan, et al.
Publicado: (2022)

An actin mechanostat ensures hyphal tip sharpness in Phytophthora infestans to achieve host penetration
por: Bronkhorst, Jochem, et al.
Publicado: (2022)

Pointed-end processive elongation of actin filaments by Vibrio effectors VopF and VopL
por: Kudryashova, Elena, et al.
Publicado: (2022)

Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics
por: Wagstaff, James Mark, et al.
Publicado: (2023)

Branched-chain actin dynamics polarizes vesicle trajectories and partitions apicobasal epithelial membrane domains
por: Jafari, Gholamali, et al.
Publicado: (2023)

Activated I-BAR IRSp53 clustering controls the formation of VASP-actin–based membrane protrusions
por: Tsai, Feng-Ching, et al.
Publicado: (2022)

Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization
por: Moehle, Erica A., et al.
Publicado: (2021)

Discovery of an F-actin–binding small molecule serving as a fluorescent probe and a scaffold for functional probes
por: Takagi, Takeru, et al.
Publicado: (2021)

Reconstitution of a minimal motility system based on Spiroplasma swimming by two bacterial actins in a synthetic minimal bacterium
por: Kiyama, Hana, et al.
Publicado: (2022)

Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression
por: Grima-Reyes, Manuel, et al.
Publicado: (2022)

Adseverin knockdown inhibits osteoclastogenesis in RAW264.7 cells
por: QI, WENTING, et al.
Publicado: (2014)

Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1
por: Song, Min-Kyoung, et al.
Publicado: (2015)

Calcium-controlled conformational choreography in the N-terminal half of adseverin
por: Chumnarnsilpa, Sakesit, et al.
Publicado: (2015)

Magnetoelectric dissociation of Alzheimer’s β-amyloid aggregates
por: Jang, Jinhyeong, et al.
Publicado: (2022)

Nerve-independent formation of membrane infoldings at topologically complex postsynaptic apparatus by caveolin-3
por: Kwan, Hui-Lam Rachel, et al.
Publicado: (2023)

An independent regulator of global release pathways in astrocytes generates a subtype of extracellular vesicles required for postsynaptic function
por: Levy-Myers, Reuben, et al.
Publicado: (2023)

Biological resurfacing in a canine model of hip osteoarthritis
por: Estes, Bradley T., et al.
Publicado: (2021)

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression
por: Zhang, Hao, et al.
Publicado: (2023)

Urchin-like ceria nanoparticles for enhanced gene therapy of osteoarthritis
por: Chen, Haoyi, et al.
Publicado: (2023)

scONE-seq: A single-cell multi-omics method enables simultaneous dissection of phenotype and genotype heterogeneity from frozen tumors
por: Yu, Lei, et al.
Publicado: (2023)

Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis
por: Lei, Yiting, et al.
Publicado: (2022)

ATM-SPARK: A GFP phase separation–based activity reporter of ATM
por: Li, Xiaoquan, et al.
Publicado: (2023)

CTR9 drives osteochondral lineage differentiation of human mesenchymal stem cells via epigenetic regulation of BMP-2 signaling
por: Chan, Ngai Ting, et al.
Publicado: (2022)

Autophagic LC3(+) calcified extracellular vesicles initiate cartilage calcification in osteoarthritis
por: Yan, Jianfei, et al.
Publicado: (2022)

Tolerogenic nanoparticles induce type II collagen–specific regulatory T cells and ameliorate osteoarthritis
por: Sohn, Hee Su, et al.
Publicado: (2022)

GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury
por: Brightwell, Camille R., et al.
Publicado: (2023)

A “best-in-class” systemic biomarker predictor of clinically relevant knee osteoarthritis structural and pain progression
por: Zhou, Kaile, et al.
Publicado: (2023)

Epigenetically mismatched parental centromeres trigger genome elimination in hybrids
por: Marimuthu, Mohan P. A., et al.
Publicado: (2021)

Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development
por: Cheu, Jacinth Wing-Sum, et al.
Publicado: (2023)

Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis
por: Wu, Yizheng, et al.
Publicado: (2023)

A self-powered multifunctional dressing for active infection prevention and accelerated wound healing
por: Barman, Snigdha Roy, et al.
Publicado: (2023)

Coupling of protein condensates to ordered lipid domains determines functional membrane organization
por: Wang, Hong-Yin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4429b237e970l438mr2pd3juiv