The role of microRNAs in pathophysiology and diagnostics of metabolic complications in obstructive sleep apnea patients

Obstructive sleep apnea (OSA) is one of the most common sleep disorders, which is characterized by recurrent apneas and/or hypopneas occurring during sleep due to upper airway obstruction. Among a variety of health consequences, OSA patients are particularly susceptible to developing metabolic compl...

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Autores principales: Karuga, Filip Franciszek, Jaromirska, Julia, Malicki, Mikołaj, Sochal, Marcin, Szmyd, Bartosz, Białasiewicz, Piotr, Strzelecki, Dominik, Gabryelska, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403239/
https://www.ncbi.nlm.nih.gov/pubmed/37547923
http://dx.doi.org/10.3389/fnmol.2023.1208886
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author Karuga, Filip Franciszek
Jaromirska, Julia
Malicki, Mikołaj
Sochal, Marcin
Szmyd, Bartosz
Białasiewicz, Piotr
Strzelecki, Dominik
Gabryelska, Agata
author_facet Karuga, Filip Franciszek
Jaromirska, Julia
Malicki, Mikołaj
Sochal, Marcin
Szmyd, Bartosz
Białasiewicz, Piotr
Strzelecki, Dominik
Gabryelska, Agata
author_sort Karuga, Filip Franciszek
collection PubMed
description Obstructive sleep apnea (OSA) is one of the most common sleep disorders, which is characterized by recurrent apneas and/or hypopneas occurring during sleep due to upper airway obstruction. Among a variety of health consequences, OSA patients are particularly susceptible to developing metabolic complications, such as metabolic syndrome and diabetes mellitus type 2. MicroRNAs (miRNAs) as epigenetic modulators are promising particles in both understanding the pathophysiology of OSA and the prediction of OSA complications. This review describes the role of miRNAs in the development of OSA-associated metabolic complications. Moreover, it summarizes the usefulness of miRNAs as biomarkers in predicting the aforementioned OSA complications.
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spelling pubmed-104032392023-08-05 The role of microRNAs in pathophysiology and diagnostics of metabolic complications in obstructive sleep apnea patients Karuga, Filip Franciszek Jaromirska, Julia Malicki, Mikołaj Sochal, Marcin Szmyd, Bartosz Białasiewicz, Piotr Strzelecki, Dominik Gabryelska, Agata Front Mol Neurosci Molecular Neuroscience Obstructive sleep apnea (OSA) is one of the most common sleep disorders, which is characterized by recurrent apneas and/or hypopneas occurring during sleep due to upper airway obstruction. Among a variety of health consequences, OSA patients are particularly susceptible to developing metabolic complications, such as metabolic syndrome and diabetes mellitus type 2. MicroRNAs (miRNAs) as epigenetic modulators are promising particles in both understanding the pathophysiology of OSA and the prediction of OSA complications. This review describes the role of miRNAs in the development of OSA-associated metabolic complications. Moreover, it summarizes the usefulness of miRNAs as biomarkers in predicting the aforementioned OSA complications. Frontiers Media S.A. 2023-07-21 /pmc/articles/PMC10403239/ /pubmed/37547923 http://dx.doi.org/10.3389/fnmol.2023.1208886 Text en Copyright © 2023 Karuga, Jaromirska, Malicki, Sochal, Szmyd, Białasiewicz, Strzelecki and Gabryelska. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Karuga, Filip Franciszek
Jaromirska, Julia
Malicki, Mikołaj
Sochal, Marcin
Szmyd, Bartosz
Białasiewicz, Piotr
Strzelecki, Dominik
Gabryelska, Agata
The role of microRNAs in pathophysiology and diagnostics of metabolic complications in obstructive sleep apnea patients
title The role of microRNAs in pathophysiology and diagnostics of metabolic complications in obstructive sleep apnea patients
title_full The role of microRNAs in pathophysiology and diagnostics of metabolic complications in obstructive sleep apnea patients
title_fullStr The role of microRNAs in pathophysiology and diagnostics of metabolic complications in obstructive sleep apnea patients
title_full_unstemmed The role of microRNAs in pathophysiology and diagnostics of metabolic complications in obstructive sleep apnea patients
title_short The role of microRNAs in pathophysiology and diagnostics of metabolic complications in obstructive sleep apnea patients
title_sort role of micrornas in pathophysiology and diagnostics of metabolic complications in obstructive sleep apnea patients
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403239/
https://www.ncbi.nlm.nih.gov/pubmed/37547923
http://dx.doi.org/10.3389/fnmol.2023.1208886
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