Puerarin alleviated oxidative stress and ferroptosis during renal fibrosis induced by ischemia/reperfusion injury via TLR4/Nox4 pathway in rats

PURPOSE: To investigate the role of puerarin on renal fibrosis and the underlying mechanism in renal ischemia and reperfusion (I/R) model. METHODS: Rats were intraperitoneally injected with puerarin (50 or 100 mg/kg) per day for one week before renal I/R. The level of renal collagen deposition and i...

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Detalles Bibliográficos
Autores principales: Jian, Jun, Wang, Dan, Xiong, Yufeng, Wang, Jingsong, Zheng, Qingyuan, Jiang, Zhengyu, Zhong, Jiacheng, Yang, Song, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403246/
https://www.ncbi.nlm.nih.gov/pubmed/37556718
http://dx.doi.org/10.1590/acb382523

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