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Resting State Network Segregation Modulates Age-Related Differences in Language Production

Older adults typically exhibit decline in language production. However, how the brain supports or fails to support these processes is unclear. Moreover, there are competing hypotheses about the nature of age-related neural changes and whether age-related increases in neural activity reflect compensa...

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Autores principales: Zhang, Haoyun, Diaz, Michele T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MIT Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403275/
https://www.ncbi.nlm.nih.gov/pubmed/37546689
http://dx.doi.org/10.1162/nol_a_00106
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author Zhang, Haoyun
Diaz, Michele T.
author_facet Zhang, Haoyun
Diaz, Michele T.
author_sort Zhang, Haoyun
collection PubMed
description Older adults typically exhibit decline in language production. However, how the brain supports or fails to support these processes is unclear. Moreover, there are competing hypotheses about the nature of age-related neural changes and whether age-related increases in neural activity reflect compensation or a decline in neural efficiency. In the current study, we investigated the neural bases of language production focusing on resting state functional connectivity. We hypothesized that language production performance, functional connectivity, and their relationship would differ as a function of age. Consistent with prior work, older age was associated with worse language production performance. Functional connectivity analyses showed that network segregation within the left hemisphere language network was maintained across adulthood. However, increased age was associated with lower whole brain network segregation. Moreover, network segregation was related to language production ability. In both network analyses, there were significant interactions with age—higher network segregation was associated with better language production abilities for younger and middle-aged adults, but not for older adults. Interestingly, there was a stronger relationship between language production and the whole brain network segregation than between production and the language network. These results highlight the utility of network segregation measures as an index of brain function, with higher network segregation associated with better language production ability. Moreover, these results are consistent with stability in the left hemisphere language network across adulthood and suggest that dedifferentiation among brain networks, outside of the language network, is a hallmark of aging and may contribute to age-related language production difficulties.
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spelling pubmed-104032752023-08-05 Resting State Network Segregation Modulates Age-Related Differences in Language Production Zhang, Haoyun Diaz, Michele T. Neurobiol Lang (Camb) Research Article Older adults typically exhibit decline in language production. However, how the brain supports or fails to support these processes is unclear. Moreover, there are competing hypotheses about the nature of age-related neural changes and whether age-related increases in neural activity reflect compensation or a decline in neural efficiency. In the current study, we investigated the neural bases of language production focusing on resting state functional connectivity. We hypothesized that language production performance, functional connectivity, and their relationship would differ as a function of age. Consistent with prior work, older age was associated with worse language production performance. Functional connectivity analyses showed that network segregation within the left hemisphere language network was maintained across adulthood. However, increased age was associated with lower whole brain network segregation. Moreover, network segregation was related to language production ability. In both network analyses, there were significant interactions with age—higher network segregation was associated with better language production abilities for younger and middle-aged adults, but not for older adults. Interestingly, there was a stronger relationship between language production and the whole brain network segregation than between production and the language network. These results highlight the utility of network segregation measures as an index of brain function, with higher network segregation associated with better language production ability. Moreover, these results are consistent with stability in the left hemisphere language network across adulthood and suggest that dedifferentiation among brain networks, outside of the language network, is a hallmark of aging and may contribute to age-related language production difficulties. MIT Press 2023-06-13 /pmc/articles/PMC10403275/ /pubmed/37546689 http://dx.doi.org/10.1162/nol_a_00106 Text en © 2023 Massachusetts Institute of Technology https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For a full description of the license, please visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Zhang, Haoyun
Diaz, Michele T.
Resting State Network Segregation Modulates Age-Related Differences in Language Production
title Resting State Network Segregation Modulates Age-Related Differences in Language Production
title_full Resting State Network Segregation Modulates Age-Related Differences in Language Production
title_fullStr Resting State Network Segregation Modulates Age-Related Differences in Language Production
title_full_unstemmed Resting State Network Segregation Modulates Age-Related Differences in Language Production
title_short Resting State Network Segregation Modulates Age-Related Differences in Language Production
title_sort resting state network segregation modulates age-related differences in language production
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403275/
https://www.ncbi.nlm.nih.gov/pubmed/37546689
http://dx.doi.org/10.1162/nol_a_00106
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