Increased hexosamine biosynthetic pathway flux alters cell–cell adhesion in INS-1E cells and murine islets

PURPOSE: In type 2 Diabetes, β-cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction (dedifferentiation, decline of glucose-stimulated insulin secretion). Apoptosis and dysfunction are caused, at least in part, by glucotoxicity, in which increased flux of g...

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Detalles Bibliográficos
Autores principales: Lofrumento, Dario Domenico, Miraglia, Alessandro, La Pesa, Velia, Treglia, Antonella Sonia, Chieppa, Marcello, De Nuccio, Francesco, Nicolardi, Giuseppe, Miele, Claudia, Beguinot, Francesco, Garbi, Corrado, Di Jeso, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403402/
https://www.ncbi.nlm.nih.gov/pubmed/37306934
http://dx.doi.org/10.1007/s12020-023-03412-9

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