DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors

The development of SARS-CoV-2 main protease (M(pro)) inhibitors for the treatment of COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of inhibitors; however, an efficient method to generate M(pro) inhibitors, which circumvents such information would be advantageous. As...

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Detalles Bibliográficos
Autores principales: Jimmidi, Ravikumar, Chamakuri, Srinivas, Lu, Shuo, Ucisik, Melek Nihan, Chen, Peng-Jen, Bohren, Kurt M., Moghadasi, Seyed Arad, Versteeg, Leroy, Nnabuife, Christina, Li, Jian-Yuan, Qin, Xuan, Chen, Ying-Chu, Faver, John C., Nyshadham, Pranavanand, Sharma, Kiran L., Sankaran, Banumathi, Judge, Allison, Yu, Zhifeng, Li, Feng, Pollet, Jeroen, Harris, Reuben S., Matzuk, Martin M., Palzkill, Timothy, Young, Damian W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403511/
https://www.ncbi.nlm.nih.gov/pubmed/37542196
http://dx.doi.org/10.1038/s42004-023-00961-y

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