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Zero- to low-field relaxometry of chemical and biological fluids

Nuclear magnetic resonance (NMR) relaxometry is an analytical method that provides information about molecular environments, even for NMR “silent” molecules (spin-0), by analyzing the properties of NMR signals versus the magnitude of the longitudinal field. Conventionally, this technique is performe...

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Autores principales: Alcicek, Seyma, Put, Piotr, Kubrak, Adam, Alcicek, Fatih Celal, Barskiy, Danila, Gloeggler, Stefan, Dybas, Jakub, Pustelny, Szymon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403525/
https://www.ncbi.nlm.nih.gov/pubmed/37542142
http://dx.doi.org/10.1038/s42004-023-00965-8
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author Alcicek, Seyma
Put, Piotr
Kubrak, Adam
Alcicek, Fatih Celal
Barskiy, Danila
Gloeggler, Stefan
Dybas, Jakub
Pustelny, Szymon
author_facet Alcicek, Seyma
Put, Piotr
Kubrak, Adam
Alcicek, Fatih Celal
Barskiy, Danila
Gloeggler, Stefan
Dybas, Jakub
Pustelny, Szymon
author_sort Alcicek, Seyma
collection PubMed
description Nuclear magnetic resonance (NMR) relaxometry is an analytical method that provides information about molecular environments, even for NMR “silent” molecules (spin-0), by analyzing the properties of NMR signals versus the magnitude of the longitudinal field. Conventionally, this technique is performed at fields much higher than Earth’s magnetic field, but our work focuses on NMR relaxometry at zero and ultra-low magnetic fields (ZULFs). Operating under such conditions allows us to investigate slow (bio)chemical processes occurring on a timescale from milliseconds to seconds, which coincide with spin evolution. ZULFs also minimize T(2) line broadening in heterogeneous samples resulting from magnetic susceptibility. Here, we use ZULF NMR relaxometry to analyze (bio)chemical compounds containing (1)H-(13)C, (1)H-(15)N, and (1)H-(31)P spin pairs. We also detected high-quality ULF NMR spectra of human whole-blood at 0.8 μT, despite a shortening of spin relaxation by blood proteomes (e.g., hemoglobin). Information on proton relaxation times of blood, a potential early biomarker of inflammation, can be acquired in under a minute using inexpensive, portable/small-size NMR spectrometers based on atomic magnetometers.
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spelling pubmed-104035252023-08-06 Zero- to low-field relaxometry of chemical and biological fluids Alcicek, Seyma Put, Piotr Kubrak, Adam Alcicek, Fatih Celal Barskiy, Danila Gloeggler, Stefan Dybas, Jakub Pustelny, Szymon Commun Chem Article Nuclear magnetic resonance (NMR) relaxometry is an analytical method that provides information about molecular environments, even for NMR “silent” molecules (spin-0), by analyzing the properties of NMR signals versus the magnitude of the longitudinal field. Conventionally, this technique is performed at fields much higher than Earth’s magnetic field, but our work focuses on NMR relaxometry at zero and ultra-low magnetic fields (ZULFs). Operating under such conditions allows us to investigate slow (bio)chemical processes occurring on a timescale from milliseconds to seconds, which coincide with spin evolution. ZULFs also minimize T(2) line broadening in heterogeneous samples resulting from magnetic susceptibility. Here, we use ZULF NMR relaxometry to analyze (bio)chemical compounds containing (1)H-(13)C, (1)H-(15)N, and (1)H-(31)P spin pairs. We also detected high-quality ULF NMR spectra of human whole-blood at 0.8 μT, despite a shortening of spin relaxation by blood proteomes (e.g., hemoglobin). Information on proton relaxation times of blood, a potential early biomarker of inflammation, can be acquired in under a minute using inexpensive, portable/small-size NMR spectrometers based on atomic magnetometers. Nature Publishing Group UK 2023-08-04 /pmc/articles/PMC10403525/ /pubmed/37542142 http://dx.doi.org/10.1038/s42004-023-00965-8 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Alcicek, Seyma
Put, Piotr
Kubrak, Adam
Alcicek, Fatih Celal
Barskiy, Danila
Gloeggler, Stefan
Dybas, Jakub
Pustelny, Szymon
Zero- to low-field relaxometry of chemical and biological fluids
title Zero- to low-field relaxometry of chemical and biological fluids
title_full Zero- to low-field relaxometry of chemical and biological fluids
title_fullStr Zero- to low-field relaxometry of chemical and biological fluids
title_full_unstemmed Zero- to low-field relaxometry of chemical and biological fluids
title_short Zero- to low-field relaxometry of chemical and biological fluids
title_sort zero- to low-field relaxometry of chemical and biological fluids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403525/
https://www.ncbi.nlm.nih.gov/pubmed/37542142
http://dx.doi.org/10.1038/s42004-023-00965-8
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