Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants

We report SARS-CoV-2 neutralizing antibody titers in sera of triple-vaccinated individuals who received a booster dose of an original monovalent or a bivalent BA.1- or BA.4/BA.5-adapted vaccine or had a breakthrough infection with Omicron variants BA.1, BA.2 or BA.4/BA.5. A bivalent BA.4/BA.5 booste...

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Autores principales: Springer, David N., Bauer, Michael, Medits, Iris, Camp, Jeremy V., Aberle, Stephan W., Burtscher, Clemens, Höltl, Eva, Weseslindtner, Lukas, Stiasny, Karin, Aberle, Judith H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403593/
https://www.ncbi.nlm.nih.gov/pubmed/37542025
http://dx.doi.org/10.1038/s41541-023-00708-9
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author Springer, David N.
Bauer, Michael
Medits, Iris
Camp, Jeremy V.
Aberle, Stephan W.
Burtscher, Clemens
Höltl, Eva
Weseslindtner, Lukas
Stiasny, Karin
Aberle, Judith H.
author_facet Springer, David N.
Bauer, Michael
Medits, Iris
Camp, Jeremy V.
Aberle, Stephan W.
Burtscher, Clemens
Höltl, Eva
Weseslindtner, Lukas
Stiasny, Karin
Aberle, Judith H.
author_sort Springer, David N.
collection PubMed
description We report SARS-CoV-2 neutralizing antibody titers in sera of triple-vaccinated individuals who received a booster dose of an original monovalent or a bivalent BA.1- or BA.4/BA.5-adapted vaccine or had a breakthrough infection with Omicron variants BA.1, BA.2 or BA.4/BA.5. A bivalent BA.4/BA.5 booster or Omicron-breakthrough infection induced increased Omicron-neutralization titers compared with the monovalent booster. The XBB.1.5 variant effectively evaded neutralizing-antibody responses elicited by current vaccines and/or infection with previous variants.
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spelling pubmed-104035932023-08-06 Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants Springer, David N. Bauer, Michael Medits, Iris Camp, Jeremy V. Aberle, Stephan W. Burtscher, Clemens Höltl, Eva Weseslindtner, Lukas Stiasny, Karin Aberle, Judith H. NPJ Vaccines Brief Communication We report SARS-CoV-2 neutralizing antibody titers in sera of triple-vaccinated individuals who received a booster dose of an original monovalent or a bivalent BA.1- or BA.4/BA.5-adapted vaccine or had a breakthrough infection with Omicron variants BA.1, BA.2 or BA.4/BA.5. A bivalent BA.4/BA.5 booster or Omicron-breakthrough infection induced increased Omicron-neutralization titers compared with the monovalent booster. The XBB.1.5 variant effectively evaded neutralizing-antibody responses elicited by current vaccines and/or infection with previous variants. Nature Publishing Group UK 2023-08-04 /pmc/articles/PMC10403593/ /pubmed/37542025 http://dx.doi.org/10.1038/s41541-023-00708-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Springer, David N.
Bauer, Michael
Medits, Iris
Camp, Jeremy V.
Aberle, Stephan W.
Burtscher, Clemens
Höltl, Eva
Weseslindtner, Lukas
Stiasny, Karin
Aberle, Judith H.
Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants
title Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants
title_full Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants
title_fullStr Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants
title_full_unstemmed Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants
title_short Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants
title_sort bivalent covid-19 mrna booster vaccination (ba.1 or ba.4/ba.5) increases neutralization of matched omicron variants
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403593/
https://www.ncbi.nlm.nih.gov/pubmed/37542025
http://dx.doi.org/10.1038/s41541-023-00708-9
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