Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during BCL-2 inhibition therapy

INTRODUCTION: Activating the aryl hydrocarbon receptor upon exposure to environmental pollutants promotes development of breast cancer stem cell (CSCs). BCL-2 family proteins protect cancer cells from the apoptotic effects of chemotherapeutic drugs. However, the crosstalk between AhR and the BCL-2 f...

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Detalles Bibliográficos
Autores principales: Al-Dhfyan, Abdullah, Alaiya, Ayodele, Al-Mohanna, Falah, Attwa, Mohamed W, AlAsmari, Abdullah F, Bakheet, Saleh A, Korashy, Hesham M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403657/
https://www.ncbi.nlm.nih.gov/pubmed/36307019
http://dx.doi.org/10.1016/j.jare.2022.10.006

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