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Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia

BACKGROUND: Females account for 60% of all living kidney donors worldwide. We defined the proportion of female to male donors for living donor kidney transplantation stratified by recipient gender, and explored the factors associated with female kidney donation. METHODS: Data from the ANZDATA (Austr...

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Autores principales: Kim, Siah, van Zwieten, Anita, Wyld, Melanie, Ladhani, Maleeka, Guha, Chandana, Dominello, Amanda, Mallitt, Kylie-Ann, Francis, Anna, Mannon, Roslyn B., Wong, Germaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403665/
https://www.ncbi.nlm.nih.gov/pubmed/37547516
http://dx.doi.org/10.1016/j.ekir.2023.05.016
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author Kim, Siah
van Zwieten, Anita
Wyld, Melanie
Ladhani, Maleeka
Guha, Chandana
Dominello, Amanda
Mallitt, Kylie-Ann
Francis, Anna
Mannon, Roslyn B.
Wong, Germaine
author_facet Kim, Siah
van Zwieten, Anita
Wyld, Melanie
Ladhani, Maleeka
Guha, Chandana
Dominello, Amanda
Mallitt, Kylie-Ann
Francis, Anna
Mannon, Roslyn B.
Wong, Germaine
author_sort Kim, Siah
collection PubMed
description BACKGROUND: Females account for 60% of all living kidney donors worldwide. We defined the proportion of female to male donors for living donor kidney transplantation stratified by recipient gender, and explored the factors associated with female kidney donation. METHODS: Data from the ANZDATA (Australian and New Zealand Dialysis and Transplantation) and ANZOD (Australian and New Zealand Organ Donor) registries (2002–2019) were used to identify the sociodemographic characteristics and their interactions associated with living donation from female donors. We derived the predicted probabilities from adjusted logistic models using marginal means. RESULTS: Of 3523 living donor pairs, 2203 (63%) recipients were male, and 2012 (57%) donors were female. Male recipients were more likely to receive kidneys from female donors than male donors. Donor and recipient sex association was modified by donor-recipient relationship (P < 0.01), with sensitivity analysis suggesting that spousal donor-recipient pairs drive this interaction. Older recipients residing in regional or remote areas were more likely to receive kidneys from female donors compared with those from major cities (aged ≥60 years: 0.67 [0.63–0.71] vs. aged <60 years: 0.57 [0.53–0.60]). CONCLUSIONS: Factors associated with female donation include recipient sex, with spousal donors contributing to the interaction between recipient gender and donor-recipient relationship. Recipient age and location of residence have interactive effects on the likelihood of living donor transplantation from female donors.
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spelling pubmed-104036652023-08-06 Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia Kim, Siah van Zwieten, Anita Wyld, Melanie Ladhani, Maleeka Guha, Chandana Dominello, Amanda Mallitt, Kylie-Ann Francis, Anna Mannon, Roslyn B. Wong, Germaine Kidney Int Rep Clinical Research BACKGROUND: Females account for 60% of all living kidney donors worldwide. We defined the proportion of female to male donors for living donor kidney transplantation stratified by recipient gender, and explored the factors associated with female kidney donation. METHODS: Data from the ANZDATA (Australian and New Zealand Dialysis and Transplantation) and ANZOD (Australian and New Zealand Organ Donor) registries (2002–2019) were used to identify the sociodemographic characteristics and their interactions associated with living donation from female donors. We derived the predicted probabilities from adjusted logistic models using marginal means. RESULTS: Of 3523 living donor pairs, 2203 (63%) recipients were male, and 2012 (57%) donors were female. Male recipients were more likely to receive kidneys from female donors than male donors. Donor and recipient sex association was modified by donor-recipient relationship (P < 0.01), with sensitivity analysis suggesting that spousal donor-recipient pairs drive this interaction. Older recipients residing in regional or remote areas were more likely to receive kidneys from female donors compared with those from major cities (aged ≥60 years: 0.67 [0.63–0.71] vs. aged <60 years: 0.57 [0.53–0.60]). CONCLUSIONS: Factors associated with female donation include recipient sex, with spousal donors contributing to the interaction between recipient gender and donor-recipient relationship. Recipient age and location of residence have interactive effects on the likelihood of living donor transplantation from female donors. Elsevier 2023-05-26 /pmc/articles/PMC10403665/ /pubmed/37547516 http://dx.doi.org/10.1016/j.ekir.2023.05.016 Text en © 2023 International Society of Nephrology. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research
Kim, Siah
van Zwieten, Anita
Wyld, Melanie
Ladhani, Maleeka
Guha, Chandana
Dominello, Amanda
Mallitt, Kylie-Ann
Francis, Anna
Mannon, Roslyn B.
Wong, Germaine
Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia
title Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia
title_full Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia
title_fullStr Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia
title_full_unstemmed Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia
title_short Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia
title_sort sociodemographic drivers of donor and recipient gender disparities in living kidney donation in australia
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403665/
https://www.ncbi.nlm.nih.gov/pubmed/37547516
http://dx.doi.org/10.1016/j.ekir.2023.05.016
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