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Pulmonary function and exercise capacity six months after hospital discharge of patients with severe COVID-19
INTRODUCTION: The long-term consequences of COVID-19, especially pulmonary impairment, are frequent but not well understood. The knowledge about sequels or long COVID-19 are necessary, considering the high prevalence and need for specific public strategies. METHOD: The study was conducted to evaluat...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403708/ https://www.ncbi.nlm.nih.gov/pubmed/37442195 http://dx.doi.org/10.1016/j.bjid.2023.102789 |
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author | Polese, Jessica Ramos, Alessandro Demoner Moulaz, Isac Ribeiro Sant'Ana, Larissa Lacerda, Bárbara Sthefany de Paula Soares, Cinthia Eduarda Santos Lança, Karen Evelin Monlevade Thompson, Beatriz Paoli Júnior, Germano Paulo Barbosa Polese Pinto, Isabella Izaita Mill, José Geraldo |
author_facet | Polese, Jessica Ramos, Alessandro Demoner Moulaz, Isac Ribeiro Sant'Ana, Larissa Lacerda, Bárbara Sthefany de Paula Soares, Cinthia Eduarda Santos Lança, Karen Evelin Monlevade Thompson, Beatriz Paoli Júnior, Germano Paulo Barbosa Polese Pinto, Isabella Izaita Mill, José Geraldo |
author_sort | Polese, Jessica |
collection | PubMed |
description | INTRODUCTION: The long-term consequences of COVID-19, especially pulmonary impairment, are frequent but not well understood. The knowledge about sequels or long COVID-19 are necessary, considering the high prevalence and need for specific public strategies. METHOD: The study was conducted to evaluate symptoms (standardized questionnaire), pulmonary function (spirometry), and exercise capacity (6-minute-walk-test) at 30 (D30), 90 (D90), and 180 (D180) days after hospital discharge of patients surviving to severe COVID-19. We excluded in this follow up patients with comorbidities before COVID infection. RESULTS: 44 patients were included and 31 (26 men) completed the 6-month follow-up (age mean 53.6 ± 9.6 years). At D180, 28% presented still at least one symptom. The most common was dyspnea (17.2%), followed by cough (13.8%), and myalgia (10.3%). All spirometric parameters showed progressive improvement from D30 to D180. However, 16% maintained a restrictive pattern on spirometry test, 44% presented desaturation on the 6-minute walk-test, and 25% walked < 75% of the predicted value. CONCLUSION: 6-months after hospital discharge, reduced pulmonary function and reduced exercise capacity was founded frequently and more than a quarter remained symptomatic. The persistent symptoms and functional impairment suggest that sequels and development of Long COVID-19 are very common. The identification of these patients to provide the necessary health care is a challenging task, considering the large number of patients infected and surviving to COVID-19 disease. |
format | Online Article Text |
id | pubmed-10403708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-104037082023-08-06 Pulmonary function and exercise capacity six months after hospital discharge of patients with severe COVID-19 Polese, Jessica Ramos, Alessandro Demoner Moulaz, Isac Ribeiro Sant'Ana, Larissa Lacerda, Bárbara Sthefany de Paula Soares, Cinthia Eduarda Santos Lança, Karen Evelin Monlevade Thompson, Beatriz Paoli Júnior, Germano Paulo Barbosa Polese Pinto, Isabella Izaita Mill, José Geraldo Braz J Infect Dis Original Article INTRODUCTION: The long-term consequences of COVID-19, especially pulmonary impairment, are frequent but not well understood. The knowledge about sequels or long COVID-19 are necessary, considering the high prevalence and need for specific public strategies. METHOD: The study was conducted to evaluate symptoms (standardized questionnaire), pulmonary function (spirometry), and exercise capacity (6-minute-walk-test) at 30 (D30), 90 (D90), and 180 (D180) days after hospital discharge of patients surviving to severe COVID-19. We excluded in this follow up patients with comorbidities before COVID infection. RESULTS: 44 patients were included and 31 (26 men) completed the 6-month follow-up (age mean 53.6 ± 9.6 years). At D180, 28% presented still at least one symptom. The most common was dyspnea (17.2%), followed by cough (13.8%), and myalgia (10.3%). All spirometric parameters showed progressive improvement from D30 to D180. However, 16% maintained a restrictive pattern on spirometry test, 44% presented desaturation on the 6-minute walk-test, and 25% walked < 75% of the predicted value. CONCLUSION: 6-months after hospital discharge, reduced pulmonary function and reduced exercise capacity was founded frequently and more than a quarter remained symptomatic. The persistent symptoms and functional impairment suggest that sequels and development of Long COVID-19 are very common. The identification of these patients to provide the necessary health care is a challenging task, considering the large number of patients infected and surviving to COVID-19 disease. Elsevier 2023-07-10 /pmc/articles/PMC10403708/ /pubmed/37442195 http://dx.doi.org/10.1016/j.bjid.2023.102789 Text en © 2023 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Polese, Jessica Ramos, Alessandro Demoner Moulaz, Isac Ribeiro Sant'Ana, Larissa Lacerda, Bárbara Sthefany de Paula Soares, Cinthia Eduarda Santos Lança, Karen Evelin Monlevade Thompson, Beatriz Paoli Júnior, Germano Paulo Barbosa Polese Pinto, Isabella Izaita Mill, José Geraldo Pulmonary function and exercise capacity six months after hospital discharge of patients with severe COVID-19 |
title | Pulmonary function and exercise capacity six months after hospital discharge of patients with severe COVID-19 |
title_full | Pulmonary function and exercise capacity six months after hospital discharge of patients with severe COVID-19 |
title_fullStr | Pulmonary function and exercise capacity six months after hospital discharge of patients with severe COVID-19 |
title_full_unstemmed | Pulmonary function and exercise capacity six months after hospital discharge of patients with severe COVID-19 |
title_short | Pulmonary function and exercise capacity six months after hospital discharge of patients with severe COVID-19 |
title_sort | pulmonary function and exercise capacity six months after hospital discharge of patients with severe covid-19 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403708/ https://www.ncbi.nlm.nih.gov/pubmed/37442195 http://dx.doi.org/10.1016/j.bjid.2023.102789 |
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