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Xanthogranulomatous cholecystitis in a patient with ulcerative colitis and primary sclerosing cholangitis: A case report

Chronic gallbladder disease due to xanthogranulomatous cholecystitis is uncommon, and its symptoms are generally vague. While there is no firm evidence to link xanthogranulomatous cholecystitis to primary sclerosing cholangitis or ulcerative colitis. The patient is a 41-year-old male with a history...

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Autores principales: Tarzamni, Mohammad Kazem, Aminzadeh Ghavifekr, Homa, Zeynalkhani, Hadise, Shirmohamadi, Masoud, Eghbali, Elham, Jafarizadeh, Ali, Ghareghoran, Seyed Siavash, Hashemizadeh, Seyedeh Elnaz, Falahatian, Masih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403711/
https://www.ncbi.nlm.nih.gov/pubmed/37547791
http://dx.doi.org/10.1016/j.radcr.2023.07.024
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author Tarzamni, Mohammad Kazem
Aminzadeh Ghavifekr, Homa
Zeynalkhani, Hadise
Shirmohamadi, Masoud
Eghbali, Elham
Jafarizadeh, Ali
Ghareghoran, Seyed Siavash
Hashemizadeh, Seyedeh Elnaz
Falahatian, Masih
author_facet Tarzamni, Mohammad Kazem
Aminzadeh Ghavifekr, Homa
Zeynalkhani, Hadise
Shirmohamadi, Masoud
Eghbali, Elham
Jafarizadeh, Ali
Ghareghoran, Seyed Siavash
Hashemizadeh, Seyedeh Elnaz
Falahatian, Masih
author_sort Tarzamni, Mohammad Kazem
collection PubMed
description Chronic gallbladder disease due to xanthogranulomatous cholecystitis is uncommon, and its symptoms are generally vague. While there is no firm evidence to link xanthogranulomatous cholecystitis to primary sclerosing cholangitis or ulcerative colitis. The patient is a 41-year-old male with a history of ulcerative colitis, primary sclerosing cholangitis, and biliary stenting who complained of symptoms of anorexia, jaundice, and pruritus. In the initial ultrasound exam, there was evidence of intrahepatic and extra-hepatic bile duct dilation along with a significant and mass-like circumferential thickening of the gallbladder wall. Magnetic resonance cholangiopancreatography was performed for further evaluation, which indicated increased gallbladder wall thickness, containing multiple T2 hyper-signal nodules while the mucosal layer was intact. There was also a filling defect in the common bile duct's distal portion. These findings matched a xanthogranulomatous cholecystitis diagnosis and a possibly malignant lesion in the distal of the common bile duct. The patient ultimately had a cholecystectomy, and pathology findings confirmed the diagnosis of xanthogranulomatous cholecystitis. Biopsy specimens obtained from the distal of the common bile duct lesion were microscopically identified as intramucosal adenocarcinoma. In patients with a history of primary sclerosing cholangitis who present with nonspecific symptoms suggesting chronic gallbladder disease and radiologic evidence of circumferential gallbladder wall thickening containing intramural nodules and intact mucosa, xanthogranulomatous cholecystitis should be kept in mind.
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spelling pubmed-104037112023-08-06 Xanthogranulomatous cholecystitis in a patient with ulcerative colitis and primary sclerosing cholangitis: A case report Tarzamni, Mohammad Kazem Aminzadeh Ghavifekr, Homa Zeynalkhani, Hadise Shirmohamadi, Masoud Eghbali, Elham Jafarizadeh, Ali Ghareghoran, Seyed Siavash Hashemizadeh, Seyedeh Elnaz Falahatian, Masih Radiol Case Rep Case Report Chronic gallbladder disease due to xanthogranulomatous cholecystitis is uncommon, and its symptoms are generally vague. While there is no firm evidence to link xanthogranulomatous cholecystitis to primary sclerosing cholangitis or ulcerative colitis. The patient is a 41-year-old male with a history of ulcerative colitis, primary sclerosing cholangitis, and biliary stenting who complained of symptoms of anorexia, jaundice, and pruritus. In the initial ultrasound exam, there was evidence of intrahepatic and extra-hepatic bile duct dilation along with a significant and mass-like circumferential thickening of the gallbladder wall. Magnetic resonance cholangiopancreatography was performed for further evaluation, which indicated increased gallbladder wall thickness, containing multiple T2 hyper-signal nodules while the mucosal layer was intact. There was also a filling defect in the common bile duct's distal portion. These findings matched a xanthogranulomatous cholecystitis diagnosis and a possibly malignant lesion in the distal of the common bile duct. The patient ultimately had a cholecystectomy, and pathology findings confirmed the diagnosis of xanthogranulomatous cholecystitis. Biopsy specimens obtained from the distal of the common bile duct lesion were microscopically identified as intramucosal adenocarcinoma. In patients with a history of primary sclerosing cholangitis who present with nonspecific symptoms suggesting chronic gallbladder disease and radiologic evidence of circumferential gallbladder wall thickening containing intramural nodules and intact mucosa, xanthogranulomatous cholecystitis should be kept in mind. Elsevier 2023-07-27 /pmc/articles/PMC10403711/ /pubmed/37547791 http://dx.doi.org/10.1016/j.radcr.2023.07.024 Text en © 2023 The Authors. Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tarzamni, Mohammad Kazem
Aminzadeh Ghavifekr, Homa
Zeynalkhani, Hadise
Shirmohamadi, Masoud
Eghbali, Elham
Jafarizadeh, Ali
Ghareghoran, Seyed Siavash
Hashemizadeh, Seyedeh Elnaz
Falahatian, Masih
Xanthogranulomatous cholecystitis in a patient with ulcerative colitis and primary sclerosing cholangitis: A case report
title Xanthogranulomatous cholecystitis in a patient with ulcerative colitis and primary sclerosing cholangitis: A case report
title_full Xanthogranulomatous cholecystitis in a patient with ulcerative colitis and primary sclerosing cholangitis: A case report
title_fullStr Xanthogranulomatous cholecystitis in a patient with ulcerative colitis and primary sclerosing cholangitis: A case report
title_full_unstemmed Xanthogranulomatous cholecystitis in a patient with ulcerative colitis and primary sclerosing cholangitis: A case report
title_short Xanthogranulomatous cholecystitis in a patient with ulcerative colitis and primary sclerosing cholangitis: A case report
title_sort xanthogranulomatous cholecystitis in a patient with ulcerative colitis and primary sclerosing cholangitis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403711/
https://www.ncbi.nlm.nih.gov/pubmed/37547791
http://dx.doi.org/10.1016/j.radcr.2023.07.024
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