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Lung cancer screening adherence among people living with and without HIV: An analysis of an integrated health system in Florida, United States (2012–2021)

Although lung cancer is a leading cause of death among people living with HIV (PLWH), limited research exists characterizing real-world lung cancer screening adherence among PLWH. Our objective was to compare low-dose computed tomography (LDCT) adherence among PLWH to those without HIV treated at on...

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Autores principales: Islam, Jessica Y., Yang, Shuang, Schabath, Matthew, Vadaparampil, Susan T., Lou, Xiwei, Wu, Yonghui, Bian, Jiang, Guo, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403735/
https://www.ncbi.nlm.nih.gov/pubmed/37546581
http://dx.doi.org/10.1016/j.pmedr.2023.102334
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author Islam, Jessica Y.
Yang, Shuang
Schabath, Matthew
Vadaparampil, Susan T.
Lou, Xiwei
Wu, Yonghui
Bian, Jiang
Guo, Yi
author_facet Islam, Jessica Y.
Yang, Shuang
Schabath, Matthew
Vadaparampil, Susan T.
Lou, Xiwei
Wu, Yonghui
Bian, Jiang
Guo, Yi
author_sort Islam, Jessica Y.
collection PubMed
description Although lung cancer is a leading cause of death among people living with HIV (PLWH), limited research exists characterizing real-world lung cancer screening adherence among PLWH. Our objective was to compare low-dose computed tomography (LDCT) adherence among PLWH to those without HIV treated at one integrated health system. Using the University of Florida’s Health Integrated Data Repository (01/01/2012–10/31/2021), we identified PLWH with at least one LDCT procedure, using Current Procedural Terminology codes(S8032/G0297/71271). Lung cancer screening adherence was defined as a second LDCT based on the Lung Imaging Reporting and Data System (Lung-RADS®). Lung-RADS categories were extracted from radiology reports using a natural language processing system. PLWH were matched with 4 randomly selected HIV-negative patients based on (+/- 1 year) age, Lung-RADS category, and calendar year. Seventy-three PLWH and 292 matched HIV-negative adults with at least one LDCT were identified. PLWH were more likely to be male (66% vs.52%,p < 0.04), non-Hispanic Black (53% vs.23%,p < 0.001), and live in an area of high poverty (45% vs.31%,p < 0.001). PLWH were more likely to be diagnosed with lung cancer after first LDCT (8% vs.0%,p < 0.001). Seventeen percent of HIV-negative and 12% of PLWH were adherent to LDCT screenings. Only 25% of PLWH diagnosed with category 4A were adherent compared to 44% of HIV-negative. On multivariable analyses, those with older age (66–80 vs.50–64 years) and with either Medicaid, charity-based, or other government insurance (vs. Medicare) were less likely to be adherent to LDCT screenings. PLWH may have poorer adherence to LDCT compared to their HIV-negative counterparts.
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spelling pubmed-104037352023-08-06 Lung cancer screening adherence among people living with and without HIV: An analysis of an integrated health system in Florida, United States (2012–2021) Islam, Jessica Y. Yang, Shuang Schabath, Matthew Vadaparampil, Susan T. Lou, Xiwei Wu, Yonghui Bian, Jiang Guo, Yi Prev Med Rep Regular Article Although lung cancer is a leading cause of death among people living with HIV (PLWH), limited research exists characterizing real-world lung cancer screening adherence among PLWH. Our objective was to compare low-dose computed tomography (LDCT) adherence among PLWH to those without HIV treated at one integrated health system. Using the University of Florida’s Health Integrated Data Repository (01/01/2012–10/31/2021), we identified PLWH with at least one LDCT procedure, using Current Procedural Terminology codes(S8032/G0297/71271). Lung cancer screening adherence was defined as a second LDCT based on the Lung Imaging Reporting and Data System (Lung-RADS®). Lung-RADS categories were extracted from radiology reports using a natural language processing system. PLWH were matched with 4 randomly selected HIV-negative patients based on (+/- 1 year) age, Lung-RADS category, and calendar year. Seventy-three PLWH and 292 matched HIV-negative adults with at least one LDCT were identified. PLWH were more likely to be male (66% vs.52%,p < 0.04), non-Hispanic Black (53% vs.23%,p < 0.001), and live in an area of high poverty (45% vs.31%,p < 0.001). PLWH were more likely to be diagnosed with lung cancer after first LDCT (8% vs.0%,p < 0.001). Seventeen percent of HIV-negative and 12% of PLWH were adherent to LDCT screenings. Only 25% of PLWH diagnosed with category 4A were adherent compared to 44% of HIV-negative. On multivariable analyses, those with older age (66–80 vs.50–64 years) and with either Medicaid, charity-based, or other government insurance (vs. Medicare) were less likely to be adherent to LDCT screenings. PLWH may have poorer adherence to LDCT compared to their HIV-negative counterparts. 2023-07-21 /pmc/articles/PMC10403735/ /pubmed/37546581 http://dx.doi.org/10.1016/j.pmedr.2023.102334 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Islam, Jessica Y.
Yang, Shuang
Schabath, Matthew
Vadaparampil, Susan T.
Lou, Xiwei
Wu, Yonghui
Bian, Jiang
Guo, Yi
Lung cancer screening adherence among people living with and without HIV: An analysis of an integrated health system in Florida, United States (2012–2021)
title Lung cancer screening adherence among people living with and without HIV: An analysis of an integrated health system in Florida, United States (2012–2021)
title_full Lung cancer screening adherence among people living with and without HIV: An analysis of an integrated health system in Florida, United States (2012–2021)
title_fullStr Lung cancer screening adherence among people living with and without HIV: An analysis of an integrated health system in Florida, United States (2012–2021)
title_full_unstemmed Lung cancer screening adherence among people living with and without HIV: An analysis of an integrated health system in Florida, United States (2012–2021)
title_short Lung cancer screening adherence among people living with and without HIV: An analysis of an integrated health system in Florida, United States (2012–2021)
title_sort lung cancer screening adherence among people living with and without hiv: an analysis of an integrated health system in florida, united states (2012–2021)
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403735/
https://www.ncbi.nlm.nih.gov/pubmed/37546581
http://dx.doi.org/10.1016/j.pmedr.2023.102334
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