VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson’s disease

BACKGROUND: Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene cause late-onset, autosomal dominant Parkinson’s disease (PD), with a single missense mutation (Asp620Asn, D620N) known to segregate with disease in families with PD. The VPS35 gene encodes a core component of the retrome...

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Detalles Bibliográficos
Autores principales: Chen, Xi, Tsika, Elpida, Levine, Nathan, Moore, Darren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403858/
https://www.ncbi.nlm.nih.gov/pubmed/37542299
http://dx.doi.org/10.1186/s13024-023-00641-4

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