BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes

Hairy cell leukemia (HCL) is a B-lymphoma induced by BRAF(V600E) mutation. However, introducing BRAF(V600E) in B-lymphocytes fails to induce hematological malignancy, suggesting that BRAF(V600E) needs concurrent mutations to drive HCL ontogeny. To resolve this issue, here we surveyed human HCL genom...

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Detalles Bibliográficos
Autores principales: Yap, Jiajun, Yuan, Jimin, Ng, Wan Hwa, Chen, Gao Bin, Sim, Yuen Rong M., Goh, Kah Chun, Teo, Joey, Lim, Trixie Y. H., Goay, Shee Min, Teo, Jia Hao Jackie, Lao, Zhentang, Lam, Paula, Sabapathy, Kanaga, Hu, Jiancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403926/
https://www.ncbi.nlm.nih.gov/pubmed/37543582
http://dx.doi.org/10.1186/s12943-023-01817-8

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