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A Case Report of Hereditary Palmoplantar Keratoderma with Esophageal Melanosis

A 70-year-old man, a known case of diabetes mellitus since 10 years ago, presented with lower limb swelling and dyspnea on exertion for one month and dysphagia to solids associated with early satiety for 2 weeks. The patient had palmoplantar keratosis (PPK), which was present since birth with a simi...

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Autores principales: Vincent Comraj, Delvina, Zainab, Ayisha, Arthur, Manisha, Chauhan, Jaba, Pandurangan, Viswanathan, Srinivasan, Devasena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Association of Gastroerterology and Hepatology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404083/
https://www.ncbi.nlm.nih.gov/pubmed/37546510
http://dx.doi.org/10.34172/mejdd.2023.335
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author Vincent Comraj, Delvina
Zainab, Ayisha
Arthur, Manisha
Chauhan, Jaba
Pandurangan, Viswanathan
Srinivasan, Devasena
author_facet Vincent Comraj, Delvina
Zainab, Ayisha
Arthur, Manisha
Chauhan, Jaba
Pandurangan, Viswanathan
Srinivasan, Devasena
author_sort Vincent Comraj, Delvina
collection PubMed
description A 70-year-old man, a known case of diabetes mellitus since 10 years ago, presented with lower limb swelling and dyspnea on exertion for one month and dysphagia to solids associated with early satiety for 2 weeks. The patient had palmoplantar keratosis (PPK), which was present since birth with a similar family history. The patient was admitted to rule out esophageal malignancy. Upper gastrointestinal gastroscopy revealed esophagitis and esophageal melanosis with gastric mucosal erythema. Biopsies samples were taken. Histopathological examination revealed reflux esophagitis and chronic active Helicobacter pylori gastritis with no evidence of malignancy. His symptoms improved following H. pylori eradication and treatment for coronary artery disease and heart failure. The patient was advised of regular follow-up as he had risk factors for the development of esophageal melanoma or squamous cell carcinoma.
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spelling pubmed-104040832023-08-06 A Case Report of Hereditary Palmoplantar Keratoderma with Esophageal Melanosis Vincent Comraj, Delvina Zainab, Ayisha Arthur, Manisha Chauhan, Jaba Pandurangan, Viswanathan Srinivasan, Devasena Middle East J Dig Dis Case Report A 70-year-old man, a known case of diabetes mellitus since 10 years ago, presented with lower limb swelling and dyspnea on exertion for one month and dysphagia to solids associated with early satiety for 2 weeks. The patient had palmoplantar keratosis (PPK), which was present since birth with a similar family history. The patient was admitted to rule out esophageal malignancy. Upper gastrointestinal gastroscopy revealed esophagitis and esophageal melanosis with gastric mucosal erythema. Biopsies samples were taken. Histopathological examination revealed reflux esophagitis and chronic active Helicobacter pylori gastritis with no evidence of malignancy. His symptoms improved following H. pylori eradication and treatment for coronary artery disease and heart failure. The patient was advised of regular follow-up as he had risk factors for the development of esophageal melanoma or squamous cell carcinoma. Iranian Association of Gastroerterology and Hepatology 2023-04 2023-04-30 /pmc/articles/PMC10404083/ /pubmed/37546510 http://dx.doi.org/10.34172/mejdd.2023.335 Text en © 2023 Middle East Journal of Digestive Diseases https://creativecommons.org/licenses/by-nc/4.0/This work is published by Middle East Journal of Digestive Diseases as an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Case Report
Vincent Comraj, Delvina
Zainab, Ayisha
Arthur, Manisha
Chauhan, Jaba
Pandurangan, Viswanathan
Srinivasan, Devasena
A Case Report of Hereditary Palmoplantar Keratoderma with Esophageal Melanosis
title A Case Report of Hereditary Palmoplantar Keratoderma with Esophageal Melanosis
title_full A Case Report of Hereditary Palmoplantar Keratoderma with Esophageal Melanosis
title_fullStr A Case Report of Hereditary Palmoplantar Keratoderma with Esophageal Melanosis
title_full_unstemmed A Case Report of Hereditary Palmoplantar Keratoderma with Esophageal Melanosis
title_short A Case Report of Hereditary Palmoplantar Keratoderma with Esophageal Melanosis
title_sort case report of hereditary palmoplantar keratoderma with esophageal melanosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404083/
https://www.ncbi.nlm.nih.gov/pubmed/37546510
http://dx.doi.org/10.34172/mejdd.2023.335
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