Cargando…

Applicability of the DPRA on mixture testing: challenges and opportunities

The in chemico direct peptide reactivity assay (DPRA) is validated to assess protein reactivity of chemical compounds, relating to the molecular initiating event of skin sensitization induction. According to OECD TG 442C, the DPRA is technically applicable to test multi-constituent substances and mi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marcelis, Quinten, Deconinck, Eric, Rogiers, Vera, Vanhaecke, Tamara, Desmedt, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Immunotoxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404183/ https://www.ncbi.nlm.nih.gov/pubmed/37414884 http://dx.doi.org/10.1007/s00204-023-03551-y

Ejemplares similares

Influence of deoxynivalenol-contaminated feed on the immune response of pigs after PRRSV vaccination and infection
por: Pierron, Alix, et al.
Publicado: (2023)

Quantifying the impact of PFOA exposure on B-cell development and antibody production
por: Taylor, Krystal D, et al.
Publicado: (2023)

Role of miR-24-3p and miR-146a-5p in dendritic cells’ maturation process induced by contact sensitizers
por: Galbiati, Valentina, et al.
Publicado: (2023)

Development of an in chemico high-throughput screening method for the identification of skin sensitization potential
por: Ferreira, Isabel, et al.
Publicado: (2023)

Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury
por: Ali, Serat-E, et al.
Publicado: (2023)

Targets and Intracellular Signaling Mechanisms for Deoxynivalenol-Induced Ribosomal RNA Cleavage
por: He, Kaiyu, et al.
Publicado: (2012)

Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha
por: Lu, Jingtao, et al.
Publicado: (2012)

Immunological impact of graphene oxide sheets in the abdominal cavity is governed by surface reactivity
por: Rodrigues, Artur Filipe, et al.
Publicado: (2018)

An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac
por: Selvaraj, Saravanakumar, et al.
Publicado: (2020)

The GARDpotency Assay for Potency-Associated Subclassification of Chemical Skin Sensitizers—Rationale, Method Development, and Ring Trial Results of Predictive Performance and Reproducibility
por: Gradin, Robin, et al.
Publicado: (2020)

Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells
por: Chen, I-Ling, et al.
Publicado: (2020)

Characterization of the Class I MHC Peptidome Resulting From DNCB Exposure of HaCaT Cells
por: Bailey, Alistair, et al.
Publicado: (2020)

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01
por: Ogese, Monday O, et al.
Publicado: (2021)

Preliminary nonclinical safety and immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs
por: Madar-Balakirski, Noa, et al.
Publicado: (2022)

Mouse innate-like B-1 lymphocytes promote inhaled particle-induced in vitro granuloma formation and inflammation in conjunction with macrophages
por: Hiéronimus, Léa, et al.
Publicado: (2021)

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity
por: Hammond, Sean, et al.
Publicado: (2021)

Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis
por: Sernoskie, Samantha Christine, et al.
Publicado: (2021)

Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque
por: Dai, Xuedong, et al.
Publicado: (2022)

rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits
por: Rosner, Amir, et al.
Publicado: (2022)

Electronic cigarette vapor exposure exaggerates the pro-inflammatory response during influenza A viral infection in human distal airway epithelium
por: Schaunaman, Niccolette, et al.
Publicado: (2022)

Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case–control study
por: Nakajima, Tamie, et al.
Publicado: (2022)

Commentary. Looking back
por: Eisen, Herman N.
Publicado: (1989)

The virulence of Streptococcus pneumoniae partially depends on dprA
por: Yu, Yi, et al.
Publicado: (2016)

Helicobacter pylori DprA alleviates restriction barrier for incoming DNA
por: Dwivedi, Gajendradhar R., et al.
Publicado: (2013)

Effects of Trichostatin A on drug uptake transporters in primary rat hepatocyte cultures
por: Ramboer, Eva, et al.
Publicado: (2015)

Molecular determinants of the DprA−RecA interaction for nucleation on ssDNA
por: Lisboa, Johnny, et al.
Publicado: (2014)

DprA from Neisseria meningitidis: properties and role in natural competence for transformation
por: Hovland, Eirik, et al.
Publicado: (2017)

In Vitro Differentiation of Embryonic and Adult Stem Cells into Hepatocytes: State of the Art
por: Snykers, Sarah, et al.
Publicado: (2009)

Current Status of Human Adipose–Derived Stem Cells: Differentiation into Hepatocyte-Like Cells
por: Al Battah, Feras, et al.
Publicado: (2011)

DprA/Smf protein localizes at the DNA uptake machinery in competent Bacillus subtilis cells
por: Tadesse, Serkalem, et al.
Publicado: (2007)

Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA
por: Wang, Wei, et al.
Publicado: (2014)

Insights into the Functional Roles of N-Terminal and C-Terminal Domains of Helicobacter pylori DprA
por: Dwivedi, Gajendradhar R., et al.
Publicado: (2015)

DprA Is Essential for Natural Competence in Riemerella anatipestifer and Has a Conserved Evolutionary Mechanism
por: Huang, Li, et al.
Publicado: (2019)

Characterization of DNA Processing Protein A (DprA) of the Radiation-Resistant Bacterium Deinococcus radiodurans
por: Sharma, Dhirendra Kumar, et al.
Publicado: (2022)

RecA Regulation by RecU and DprA During Bacillus subtilis Natural Plasmid Transformation
por: Serrano, Ester, et al.
Publicado: (2018)

Screening of repeated dose toxicity data in safety evaluation reports of cosmetic ingredients issued by the Scientific Committee on Consumer Safety between 2009 and 2019
por: Gustafson, Emma, et al.
Publicado: (2020)

COVID-19 and drug-induced liver injury: a problem of plenty or a petty point?
por: Boeckmans, Joost, et al.
Publicado: (2020)

Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology
por: Joanna, Fraczek, et al.
Publicado: (2009)

Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples
por: Rodrigues, Robim M., et al.
Publicado: (2016)

Bacillus subtilis RecA with DprA–SsbA antagonizes RecX function during natural transformation
por: Le, Shimin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_1vjd8sb8gj6iodbjddifcvbum3