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Plasmodium berghei oocysts possess fatty acid synthesis and scavenging routes

Malaria parasites carry out fatty acid synthesis (FAS) in their apicoplast organelle via a bacterially related (type II) enzymatic pathway. In the vertebrate host, exoerythrocytic Plasmodium stages rely on FAS, whereas intraerythrocytic stages depend on scavenging FA from their environment. In the m...

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Autores principales: Saeed, Sadia, Tremp, Annie Z., Dessens, Johannes T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404217/
https://www.ncbi.nlm.nih.gov/pubmed/37543672
http://dx.doi.org/10.1038/s41598-023-39708-z
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author Saeed, Sadia
Tremp, Annie Z.
Dessens, Johannes T.
author_facet Saeed, Sadia
Tremp, Annie Z.
Dessens, Johannes T.
author_sort Saeed, Sadia
collection PubMed
description Malaria parasites carry out fatty acid synthesis (FAS) in their apicoplast organelle via a bacterially related (type II) enzymatic pathway. In the vertebrate host, exoerythrocytic Plasmodium stages rely on FAS, whereas intraerythrocytic stages depend on scavenging FA from their environment. In the mosquito, P. falciparum oocysts express and rely on FAS enzymes for sporozoite formation, but P. yoelii oocysts do not express, nor depend on, FAS enzymes and thus rely on FA scavenging to support sporogony. In P. berghei, FAS enzymes are similarly expendable for sporogony, indicating it conforms to the P. yoelii scenario. We show here that P. berghei, unexpectedly, expresses FAS enzymes throughout oocyst development. These findings indicate that P. berghei can employ FAS alongside FA scavenging to maximise sporogony and transmission, and is more similar to P. falciparum than previously assumed with respect to FA acquisition by the oocyst. The ability of oocysts to switch between FAS and scavenging could be an important factor in the non-competitive relationship of resource exploitation between Plasmodium parasites and their mosquito vectors, which shapes parasite virulence both in the insect and vertebrate.
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spelling pubmed-104042172023-08-07 Plasmodium berghei oocysts possess fatty acid synthesis and scavenging routes Saeed, Sadia Tremp, Annie Z. Dessens, Johannes T. Sci Rep Article Malaria parasites carry out fatty acid synthesis (FAS) in their apicoplast organelle via a bacterially related (type II) enzymatic pathway. In the vertebrate host, exoerythrocytic Plasmodium stages rely on FAS, whereas intraerythrocytic stages depend on scavenging FA from their environment. In the mosquito, P. falciparum oocysts express and rely on FAS enzymes for sporozoite formation, but P. yoelii oocysts do not express, nor depend on, FAS enzymes and thus rely on FA scavenging to support sporogony. In P. berghei, FAS enzymes are similarly expendable for sporogony, indicating it conforms to the P. yoelii scenario. We show here that P. berghei, unexpectedly, expresses FAS enzymes throughout oocyst development. These findings indicate that P. berghei can employ FAS alongside FA scavenging to maximise sporogony and transmission, and is more similar to P. falciparum than previously assumed with respect to FA acquisition by the oocyst. The ability of oocysts to switch between FAS and scavenging could be an important factor in the non-competitive relationship of resource exploitation between Plasmodium parasites and their mosquito vectors, which shapes parasite virulence both in the insect and vertebrate. Nature Publishing Group UK 2023-08-05 /pmc/articles/PMC10404217/ /pubmed/37543672 http://dx.doi.org/10.1038/s41598-023-39708-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Saeed, Sadia
Tremp, Annie Z.
Dessens, Johannes T.
Plasmodium berghei oocysts possess fatty acid synthesis and scavenging routes
title Plasmodium berghei oocysts possess fatty acid synthesis and scavenging routes
title_full Plasmodium berghei oocysts possess fatty acid synthesis and scavenging routes
title_fullStr Plasmodium berghei oocysts possess fatty acid synthesis and scavenging routes
title_full_unstemmed Plasmodium berghei oocysts possess fatty acid synthesis and scavenging routes
title_short Plasmodium berghei oocysts possess fatty acid synthesis and scavenging routes
title_sort plasmodium berghei oocysts possess fatty acid synthesis and scavenging routes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404217/
https://www.ncbi.nlm.nih.gov/pubmed/37543672
http://dx.doi.org/10.1038/s41598-023-39708-z
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