Cargando…
Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A
Elective single-embryo transfers of euploid or low-level mosaic blastocysts were analyzed in this retrospective study to determine the correlations of live birth (LB) probability with embryonic developmental features of implanted day 5 (D5, n = 245) or day 6 (D6, n = 73) blastocysts using time-lapse...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404267/ https://www.ncbi.nlm.nih.gov/pubmed/37543691 http://dx.doi.org/10.1038/s41598-023-40052-5 |
_version_ | 1785085261201276928 |
---|---|
author | Chen, Chien-Hong Lee, Chun-I Huang, Chun-Chia Chen, Hsiu-Hui Chang, Chih-Ying Cheng, En-Hui Lin, Pin-Yao Chen, Chung-I Lee, Tsung-Hsien Lee, Maw-Sheng |
author_facet | Chen, Chien-Hong Lee, Chun-I Huang, Chun-Chia Chen, Hsiu-Hui Chang, Chih-Ying Cheng, En-Hui Lin, Pin-Yao Chen, Chung-I Lee, Tsung-Hsien Lee, Maw-Sheng |
author_sort | Chen, Chien-Hong |
collection | PubMed |
description | Elective single-embryo transfers of euploid or low-level mosaic blastocysts were analyzed in this retrospective study to determine the correlations of live birth (LB) probability with embryonic developmental features of implanted day 5 (D5, n = 245) or day 6 (D6, n = 73) blastocysts using time-lapse (TL) monitoring. According to the logistic regression analyses (adjusted odds ratio [OR] = 0.341, 95% confidence interval [CI] = 0.169–0.685, P < 0.05), the LB probability was negatively associated with the D6 group. The LB rate of the D5 group was higher than the D6 group (88.2% vs. 75.3%; P < 0.05). Compared with the D5 blastocysts, the D6 blastocysts exhibited comparable dysmorphisms except for the multinucleation at the 4-cell stage (10.9% vs. 2.9%, P < 0.05). Moreover, D6 blastocysts had considerably slower developmental kinetics and poorer blastocyst morphologies. Further analysis confirmed that the LB rate was not associated with developmental kinetics or dysmorphisms but rather with blastocyst morphology (inner cell mass [ICM] grade ≤ C vs. ICM grade A, adjusted OR = 0.155, 95% CI = 0.04–0.596, P < 0.05; trophectoderm [TE] grade ≤ C vs. TE grade A, adjusted OR = 0.157, 95% CI = 0.032–0.760, P < 0.05). In conclusion, D6 implanted blastocysts have a considerably lower LB rate than D5 implanted blastocysts. As determined by TL monitoring, the diminished blastocyst morphology can be one of the primary reasons underlying the decreased likelihood of LB. |
format | Online Article Text |
id | pubmed-10404267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104042672023-08-07 Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A Chen, Chien-Hong Lee, Chun-I Huang, Chun-Chia Chen, Hsiu-Hui Chang, Chih-Ying Cheng, En-Hui Lin, Pin-Yao Chen, Chung-I Lee, Tsung-Hsien Lee, Maw-Sheng Sci Rep Article Elective single-embryo transfers of euploid or low-level mosaic blastocysts were analyzed in this retrospective study to determine the correlations of live birth (LB) probability with embryonic developmental features of implanted day 5 (D5, n = 245) or day 6 (D6, n = 73) blastocysts using time-lapse (TL) monitoring. According to the logistic regression analyses (adjusted odds ratio [OR] = 0.341, 95% confidence interval [CI] = 0.169–0.685, P < 0.05), the LB probability was negatively associated with the D6 group. The LB rate of the D5 group was higher than the D6 group (88.2% vs. 75.3%; P < 0.05). Compared with the D5 blastocysts, the D6 blastocysts exhibited comparable dysmorphisms except for the multinucleation at the 4-cell stage (10.9% vs. 2.9%, P < 0.05). Moreover, D6 blastocysts had considerably slower developmental kinetics and poorer blastocyst morphologies. Further analysis confirmed that the LB rate was not associated with developmental kinetics or dysmorphisms but rather with blastocyst morphology (inner cell mass [ICM] grade ≤ C vs. ICM grade A, adjusted OR = 0.155, 95% CI = 0.04–0.596, P < 0.05; trophectoderm [TE] grade ≤ C vs. TE grade A, adjusted OR = 0.157, 95% CI = 0.032–0.760, P < 0.05). In conclusion, D6 implanted blastocysts have a considerably lower LB rate than D5 implanted blastocysts. As determined by TL monitoring, the diminished blastocyst morphology can be one of the primary reasons underlying the decreased likelihood of LB. Nature Publishing Group UK 2023-08-05 /pmc/articles/PMC10404267/ /pubmed/37543691 http://dx.doi.org/10.1038/s41598-023-40052-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Chen, Chien-Hong Lee, Chun-I Huang, Chun-Chia Chen, Hsiu-Hui Chang, Chih-Ying Cheng, En-Hui Lin, Pin-Yao Chen, Chung-I Lee, Tsung-Hsien Lee, Maw-Sheng Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A |
title | Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A |
title_full | Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A |
title_fullStr | Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A |
title_full_unstemmed | Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A |
title_short | Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A |
title_sort | increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with pgt-a |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404267/ https://www.ncbi.nlm.nih.gov/pubmed/37543691 http://dx.doi.org/10.1038/s41598-023-40052-5 |
work_keys_str_mv | AT chenchienhong increasedincidenceoflivebirthsinimplantedday5versusday6blastocystsfollowingsingleembryotransferswithpgta AT leechuni increasedincidenceoflivebirthsinimplantedday5versusday6blastocystsfollowingsingleembryotransferswithpgta AT huangchunchia increasedincidenceoflivebirthsinimplantedday5versusday6blastocystsfollowingsingleembryotransferswithpgta AT chenhsiuhui increasedincidenceoflivebirthsinimplantedday5versusday6blastocystsfollowingsingleembryotransferswithpgta AT changchihying increasedincidenceoflivebirthsinimplantedday5versusday6blastocystsfollowingsingleembryotransferswithpgta AT chengenhui increasedincidenceoflivebirthsinimplantedday5versusday6blastocystsfollowingsingleembryotransferswithpgta AT linpinyao increasedincidenceoflivebirthsinimplantedday5versusday6blastocystsfollowingsingleembryotransferswithpgta AT chenchungi increasedincidenceoflivebirthsinimplantedday5versusday6blastocystsfollowingsingleembryotransferswithpgta AT leetsunghsien increasedincidenceoflivebirthsinimplantedday5versusday6blastocystsfollowingsingleembryotransferswithpgta AT leemawsheng increasedincidenceoflivebirthsinimplantedday5versusday6blastocystsfollowingsingleembryotransferswithpgta |