Multi-PGS enhances polygenic prediction by combining 937 polygenic scores

The predictive performance of polygenic scores (PGS) is largely dependent on the number of samples available to train the PGS. Increasing the sample size for a specific phenotype is expensive and takes time, but this sample size can be effectively increased by using genetically correlated phenotypes...

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Detalles Bibliográficos
Autores principales: Albiñana, Clara, Zhu, Zhihong, Schork, Andrew J., Ingason, Andrés, Aschard, Hugues, Brikell, Isabell, Bulik, Cynthia M., Petersen, Liselotte V., Agerbo, Esben, Grove, Jakob, Nordentoft, Merete, Hougaard, David M., Werge, Thomas, Børglum, Anders D., Mortensen, Preben Bo, McGrath, John J., Neale, Benjamin M., Privé, Florian, Vilhjálmsson, Bjarni J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404269/
https://www.ncbi.nlm.nih.gov/pubmed/37543680
http://dx.doi.org/10.1038/s41467-023-40330-w

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