Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1

Regulation of protein translation initiation is tightly associated with cell growth and survival. Here, we identify Paip1, the Drosophila homolog of the translation initiation factor PAIP1, and analyze its role during development. Through genetic analysis, we find that loss of Paip1 causes reduced p...

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Detalles Bibliográficos
Autores principales: Xue, Maoguang, Cong, Fei, Zheng, Wanling, Xu, Ruoqing, Liu, Xiaoyu, Bao, Hongcun, Sung, Ying Ying, Xi, Yongmei, He, Feng, Ma, Jun, Yang, Xiaohang, Ge, Wanzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404277/
https://www.ncbi.nlm.nih.gov/pubmed/37543696
http://dx.doi.org/10.1038/s41420-023-01587-8

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