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A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET)

Gastrointestinal neuroectodermal tumors (GNETs) are extremely rare and intriguing malignancies originating from neural crest cells in the digestive tract. The digestive tract's neural crest cells can give rise to incredibly unusual and interesting gastrointestinal neuroectodermal tumors (GNETs)...

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Detalles Bibliográficos
Autores principales: Saeed, Shahzeb, Grezenko, Han, Nisar, Lyba, Rehman, Abdur, Riyaz, Amina, Cook, Daniel E, Kamran, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404388/
https://www.ncbi.nlm.nih.gov/pubmed/37551252
http://dx.doi.org/10.7759/cureus.41509
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author Saeed, Shahzeb
Grezenko, Han
Nisar, Lyba
Rehman, Abdur
Riyaz, Amina
Cook, Daniel E
Kamran, Muhammad
author_facet Saeed, Shahzeb
Grezenko, Han
Nisar, Lyba
Rehman, Abdur
Riyaz, Amina
Cook, Daniel E
Kamran, Muhammad
author_sort Saeed, Shahzeb
collection PubMed
description Gastrointestinal neuroectodermal tumors (GNETs) are extremely rare and intriguing malignancies originating from neural crest cells in the digestive tract. The digestive tract's neural crest cells can give rise to incredibly unusual and interesting gastrointestinal neuroectodermal tumors (GNETs). GNETs present considerable hurdles in diagnosis and management because of their rarity and varied expression. In this case report, a 45-year-old male patient is described who had signs of GNET, such as exhaustion, weight loss, and abdominal pain. A 7-cm jejunum tumor and related thickening of the gut wall were discovered using imaging investigations. The diagnosis of malignant GNET was confirmed by surgical resection, and adjuvant treatment was given. A recurring tumor required a second surgical procedure despite an initial disease-free period. The report emphasizes the difficulties involved in the diagnosis, treatment, and long-term effects of GNETs. The rarity of GNETs necessitates the development of standardized treatment protocols as well as additional research to enhance diagnostic precision and explore novel therapeutic approaches for this aggressive malignancy.
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spelling pubmed-104043882023-08-07 A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET) Saeed, Shahzeb Grezenko, Han Nisar, Lyba Rehman, Abdur Riyaz, Amina Cook, Daniel E Kamran, Muhammad Cureus Pathology Gastrointestinal neuroectodermal tumors (GNETs) are extremely rare and intriguing malignancies originating from neural crest cells in the digestive tract. The digestive tract's neural crest cells can give rise to incredibly unusual and interesting gastrointestinal neuroectodermal tumors (GNETs). GNETs present considerable hurdles in diagnosis and management because of their rarity and varied expression. In this case report, a 45-year-old male patient is described who had signs of GNET, such as exhaustion, weight loss, and abdominal pain. A 7-cm jejunum tumor and related thickening of the gut wall were discovered using imaging investigations. The diagnosis of malignant GNET was confirmed by surgical resection, and adjuvant treatment was given. A recurring tumor required a second surgical procedure despite an initial disease-free period. The report emphasizes the difficulties involved in the diagnosis, treatment, and long-term effects of GNETs. The rarity of GNETs necessitates the development of standardized treatment protocols as well as additional research to enhance diagnostic precision and explore novel therapeutic approaches for this aggressive malignancy. Cureus 2023-07-07 /pmc/articles/PMC10404388/ /pubmed/37551252 http://dx.doi.org/10.7759/cureus.41509 Text en Copyright © 2023, Saeed et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Saeed, Shahzeb
Grezenko, Han
Nisar, Lyba
Rehman, Abdur
Riyaz, Amina
Cook, Daniel E
Kamran, Muhammad
A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET)
title A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET)
title_full A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET)
title_fullStr A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET)
title_full_unstemmed A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET)
title_short A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET)
title_sort rare but aggressive malignancy: a case report of a gastrointestinal neuroectodermal tumor (gnet)
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404388/
https://www.ncbi.nlm.nih.gov/pubmed/37551252
http://dx.doi.org/10.7759/cureus.41509
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