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A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET)
Gastrointestinal neuroectodermal tumors (GNETs) are extremely rare and intriguing malignancies originating from neural crest cells in the digestive tract. The digestive tract's neural crest cells can give rise to incredibly unusual and interesting gastrointestinal neuroectodermal tumors (GNETs)...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404388/ https://www.ncbi.nlm.nih.gov/pubmed/37551252 http://dx.doi.org/10.7759/cureus.41509 |
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author | Saeed, Shahzeb Grezenko, Han Nisar, Lyba Rehman, Abdur Riyaz, Amina Cook, Daniel E Kamran, Muhammad |
author_facet | Saeed, Shahzeb Grezenko, Han Nisar, Lyba Rehman, Abdur Riyaz, Amina Cook, Daniel E Kamran, Muhammad |
author_sort | Saeed, Shahzeb |
collection | PubMed |
description | Gastrointestinal neuroectodermal tumors (GNETs) are extremely rare and intriguing malignancies originating from neural crest cells in the digestive tract. The digestive tract's neural crest cells can give rise to incredibly unusual and interesting gastrointestinal neuroectodermal tumors (GNETs). GNETs present considerable hurdles in diagnosis and management because of their rarity and varied expression. In this case report, a 45-year-old male patient is described who had signs of GNET, such as exhaustion, weight loss, and abdominal pain. A 7-cm jejunum tumor and related thickening of the gut wall were discovered using imaging investigations. The diagnosis of malignant GNET was confirmed by surgical resection, and adjuvant treatment was given. A recurring tumor required a second surgical procedure despite an initial disease-free period. The report emphasizes the difficulties involved in the diagnosis, treatment, and long-term effects of GNETs. The rarity of GNETs necessitates the development of standardized treatment protocols as well as additional research to enhance diagnostic precision and explore novel therapeutic approaches for this aggressive malignancy. |
format | Online Article Text |
id | pubmed-10404388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-104043882023-08-07 A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET) Saeed, Shahzeb Grezenko, Han Nisar, Lyba Rehman, Abdur Riyaz, Amina Cook, Daniel E Kamran, Muhammad Cureus Pathology Gastrointestinal neuroectodermal tumors (GNETs) are extremely rare and intriguing malignancies originating from neural crest cells in the digestive tract. The digestive tract's neural crest cells can give rise to incredibly unusual and interesting gastrointestinal neuroectodermal tumors (GNETs). GNETs present considerable hurdles in diagnosis and management because of their rarity and varied expression. In this case report, a 45-year-old male patient is described who had signs of GNET, such as exhaustion, weight loss, and abdominal pain. A 7-cm jejunum tumor and related thickening of the gut wall were discovered using imaging investigations. The diagnosis of malignant GNET was confirmed by surgical resection, and adjuvant treatment was given. A recurring tumor required a second surgical procedure despite an initial disease-free period. The report emphasizes the difficulties involved in the diagnosis, treatment, and long-term effects of GNETs. The rarity of GNETs necessitates the development of standardized treatment protocols as well as additional research to enhance diagnostic precision and explore novel therapeutic approaches for this aggressive malignancy. Cureus 2023-07-07 /pmc/articles/PMC10404388/ /pubmed/37551252 http://dx.doi.org/10.7759/cureus.41509 Text en Copyright © 2023, Saeed et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pathology Saeed, Shahzeb Grezenko, Han Nisar, Lyba Rehman, Abdur Riyaz, Amina Cook, Daniel E Kamran, Muhammad A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET) |
title | A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET) |
title_full | A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET) |
title_fullStr | A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET) |
title_full_unstemmed | A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET) |
title_short | A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET) |
title_sort | rare but aggressive malignancy: a case report of a gastrointestinal neuroectodermal tumor (gnet) |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404388/ https://www.ncbi.nlm.nih.gov/pubmed/37551252 http://dx.doi.org/10.7759/cureus.41509 |
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