Cargando…
Clinical Characteristics and Prognosis of Hospital-Acquired Klebsiella pneumoniae Bacteremic Pneumonia versus Escherichia coli Bacteremic Pneumonia: A Retrospective Comparative Study
OBJECTIVE: This research aimed to investigate the variations in clinical features and prognosis of HABP caused by E. coli and K. pneumoniae. We also aimed to evaluate the risk variables related to 30-day death in the investigated groups. METHODS: A single-center retrospective cohort research lasting...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404434/ https://www.ncbi.nlm.nih.gov/pubmed/37551280 http://dx.doi.org/10.2147/IDR.S419699 |
_version_ | 1785085297955962880 |
---|---|
author | Li, Fuxing Zhu, Junqi Hang, Yaping Chen, Yanhui Gu, Shumin Peng, Suqin Fang, Youling Hu, Longhua Xiong, Jianqiu |
author_facet | Li, Fuxing Zhu, Junqi Hang, Yaping Chen, Yanhui Gu, Shumin Peng, Suqin Fang, Youling Hu, Longhua Xiong, Jianqiu |
author_sort | Li, Fuxing |
collection | PubMed |
description | OBJECTIVE: This research aimed to investigate the variations in clinical features and prognosis of HABP caused by E. coli and K. pneumoniae. We also aimed to evaluate the risk variables related to 30-day death in the investigated groups. METHODS: A single-center retrospective cohort research lasting four years was performed. A total of 117 patients with HABP were involved in this research. The primary prognosis was 30-day death. RESULTS: Among 117 patients with HABP, 60 patients were infected with K. pneumoniae (KP-HABP), and 57 patients were infected with E. coli (E. coli-HABP). A higher proportion of males, ICU admission, undergoing tracheotomy and trachea cannulation, carbapenem-resistant strains, inappropriate empirical therapy (IET), immune compromise, diabetes mellitus, and sepsis were observed in the patients with KP-HABP (all P < 0.05). Meanwhile, the median SOFA score and Pitt score were significantly (P < 0.001) higher in the KP-HABP group compared to the E. coli-HABP group. The 30-day death was 48.33% in the KP-HABP group and 24.56% in the E. coli-HABP group (P = 0.008). After adjusting for the main covariates, the hazard ratios for 30-day mortality in KP-HABP were 1.58 (95% CI:0.80–3.12), 3.24 (95% CI:1.48–7.06), 5.67 (95% CI:2.00–16.07), and 5.99 (95% CI:2.10–17.06), respectively. Multivariate logistic regression models revealed that IET, hypoproteinaemia, cerebral vascular disease (CVD), and SOFA score ≥ 5.0 were the independent risk variables for 30-day death in KP-HABP. Simultaneously, SOFA score ≥ 4.0 and Pitt score ≥ 2.0 were independent risk factors for 30-day mortality in E. coli-HABP. CONCLUSION: The clinical features of HABP vary depending on whether it is caused by Escherichia coli or K. pneumoniae. KP-HABP patients have higher 30-day mortality than E. coli-HABP patients. To ensure greater validity, it is necessary to further verify this conclusion using a larger sample size. |
format | Online Article Text |
id | pubmed-10404434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-104044342023-08-07 Clinical Characteristics and Prognosis of Hospital-Acquired Klebsiella pneumoniae Bacteremic Pneumonia versus Escherichia coli Bacteremic Pneumonia: A Retrospective Comparative Study Li, Fuxing Zhu, Junqi Hang, Yaping Chen, Yanhui Gu, Shumin Peng, Suqin Fang, Youling Hu, Longhua Xiong, Jianqiu Infect Drug Resist Original Research OBJECTIVE: This research aimed to investigate the variations in clinical features and prognosis of HABP caused by E. coli and K. pneumoniae. We also aimed to evaluate the risk variables related to 30-day death in the investigated groups. METHODS: A single-center retrospective cohort research lasting four years was performed. A total of 117 patients with HABP were involved in this research. The primary prognosis was 30-day death. RESULTS: Among 117 patients with HABP, 60 patients were infected with K. pneumoniae (KP-HABP), and 57 patients were infected with E. coli (E. coli-HABP). A higher proportion of males, ICU admission, undergoing tracheotomy and trachea cannulation, carbapenem-resistant strains, inappropriate empirical therapy (IET), immune compromise, diabetes mellitus, and sepsis were observed in the patients with KP-HABP (all P < 0.05). Meanwhile, the median SOFA score and Pitt score were significantly (P < 0.001) higher in the KP-HABP group compared to the E. coli-HABP group. The 30-day death was 48.33% in the KP-HABP group and 24.56% in the E. coli-HABP group (P = 0.008). After adjusting for the main covariates, the hazard ratios for 30-day mortality in KP-HABP were 1.58 (95% CI:0.80–3.12), 3.24 (95% CI:1.48–7.06), 5.67 (95% CI:2.00–16.07), and 5.99 (95% CI:2.10–17.06), respectively. Multivariate logistic regression models revealed that IET, hypoproteinaemia, cerebral vascular disease (CVD), and SOFA score ≥ 5.0 were the independent risk variables for 30-day death in KP-HABP. Simultaneously, SOFA score ≥ 4.0 and Pitt score ≥ 2.0 were independent risk factors for 30-day mortality in E. coli-HABP. CONCLUSION: The clinical features of HABP vary depending on whether it is caused by Escherichia coli or K. pneumoniae. KP-HABP patients have higher 30-day mortality than E. coli-HABP patients. To ensure greater validity, it is necessary to further verify this conclusion using a larger sample size. Dove 2023-08-02 /pmc/articles/PMC10404434/ /pubmed/37551280 http://dx.doi.org/10.2147/IDR.S419699 Text en © 2023 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Li, Fuxing Zhu, Junqi Hang, Yaping Chen, Yanhui Gu, Shumin Peng, Suqin Fang, Youling Hu, Longhua Xiong, Jianqiu Clinical Characteristics and Prognosis of Hospital-Acquired Klebsiella pneumoniae Bacteremic Pneumonia versus Escherichia coli Bacteremic Pneumonia: A Retrospective Comparative Study |
title | Clinical Characteristics and Prognosis of Hospital-Acquired Klebsiella pneumoniae Bacteremic Pneumonia versus Escherichia coli Bacteremic Pneumonia: A Retrospective Comparative Study |
title_full | Clinical Characteristics and Prognosis of Hospital-Acquired Klebsiella pneumoniae Bacteremic Pneumonia versus Escherichia coli Bacteremic Pneumonia: A Retrospective Comparative Study |
title_fullStr | Clinical Characteristics and Prognosis of Hospital-Acquired Klebsiella pneumoniae Bacteremic Pneumonia versus Escherichia coli Bacteremic Pneumonia: A Retrospective Comparative Study |
title_full_unstemmed | Clinical Characteristics and Prognosis of Hospital-Acquired Klebsiella pneumoniae Bacteremic Pneumonia versus Escherichia coli Bacteremic Pneumonia: A Retrospective Comparative Study |
title_short | Clinical Characteristics and Prognosis of Hospital-Acquired Klebsiella pneumoniae Bacteremic Pneumonia versus Escherichia coli Bacteremic Pneumonia: A Retrospective Comparative Study |
title_sort | clinical characteristics and prognosis of hospital-acquired klebsiella pneumoniae bacteremic pneumonia versus escherichia coli bacteremic pneumonia: a retrospective comparative study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404434/ https://www.ncbi.nlm.nih.gov/pubmed/37551280 http://dx.doi.org/10.2147/IDR.S419699 |
work_keys_str_mv | AT lifuxing clinicalcharacteristicsandprognosisofhospitalacquiredklebsiellapneumoniaebacteremicpneumoniaversusescherichiacolibacteremicpneumoniaaretrospectivecomparativestudy AT zhujunqi clinicalcharacteristicsandprognosisofhospitalacquiredklebsiellapneumoniaebacteremicpneumoniaversusescherichiacolibacteremicpneumoniaaretrospectivecomparativestudy AT hangyaping clinicalcharacteristicsandprognosisofhospitalacquiredklebsiellapneumoniaebacteremicpneumoniaversusescherichiacolibacteremicpneumoniaaretrospectivecomparativestudy AT chenyanhui clinicalcharacteristicsandprognosisofhospitalacquiredklebsiellapneumoniaebacteremicpneumoniaversusescherichiacolibacteremicpneumoniaaretrospectivecomparativestudy AT gushumin clinicalcharacteristicsandprognosisofhospitalacquiredklebsiellapneumoniaebacteremicpneumoniaversusescherichiacolibacteremicpneumoniaaretrospectivecomparativestudy AT pengsuqin clinicalcharacteristicsandprognosisofhospitalacquiredklebsiellapneumoniaebacteremicpneumoniaversusescherichiacolibacteremicpneumoniaaretrospectivecomparativestudy AT fangyouling clinicalcharacteristicsandprognosisofhospitalacquiredklebsiellapneumoniaebacteremicpneumoniaversusescherichiacolibacteremicpneumoniaaretrospectivecomparativestudy AT hulonghua clinicalcharacteristicsandprognosisofhospitalacquiredklebsiellapneumoniaebacteremicpneumoniaversusescherichiacolibacteremicpneumoniaaretrospectivecomparativestudy AT xiongjianqiu clinicalcharacteristicsandprognosisofhospitalacquiredklebsiellapneumoniaebacteremicpneumoniaversusescherichiacolibacteremicpneumoniaaretrospectivecomparativestudy |