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Rapid phosphorylation of glucose-6-phosphate dehydrogenase by casein kinase 2 sustains redox homeostasis under ionizing radiation

Exposure to ionizing radiation leads to oxidative damages in living cells. NADPH provides the indispensable reducing power to regenerate the reduced glutathione to maintain cellular redox equilibria. In mammalian cells, pentose phosphate pathway (PPP) is the major route to produce NADPH by using gly...

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Detalles Bibliográficos
Autores principales: Hao, Yilong, Ren, Tao, Huang, Xiaoke, Li, Mi, Lee, Jong-Ho, Chen, Qianming, Liu, Rui, Tang, Qingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404535/
https://www.ncbi.nlm.nih.gov/pubmed/37478541
http://dx.doi.org/10.1016/j.redox.2023.102810