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Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?()
BACKGROUND: Psoriasis is a chronic inflammatory disease that is associated with many inflammatory conditions such as atherosclerosis, hypertension, among others. SCUBE-1 is a protein that plays a role in angiogenesis. OBJECTIVES: The present study aimed to investigate whether SCUBE-1 could indicate...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404550/ https://www.ncbi.nlm.nih.gov/pubmed/37198010 http://dx.doi.org/10.1016/j.abd.2022.08.012 |
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author | Ayvaz Çelik, Havva Hilal Kuyumcu, Mevlüt Serdar Şirin, Fevziye Burcu Cirit, Mehmet Korkmaz, Selma Erturan, İjlal Çelik, Seda Yıldırım, Mehmet |
author_facet | Ayvaz Çelik, Havva Hilal Kuyumcu, Mevlüt Serdar Şirin, Fevziye Burcu Cirit, Mehmet Korkmaz, Selma Erturan, İjlal Çelik, Seda Yıldırım, Mehmet |
author_sort | Ayvaz Çelik, Havva Hilal |
collection | PubMed |
description | BACKGROUND: Psoriasis is a chronic inflammatory disease that is associated with many inflammatory conditions such as atherosclerosis, hypertension, among others. SCUBE-1 is a protein that plays a role in angiogenesis. OBJECTIVES: The present study aimed to investigate whether SCUBE-1 could indicate subclinical atherosclerosis in psoriatic patients, and to compare SCUBE-1 levels, measurement of carotid artery ıntima-media thickness (CIMT), and metabolic parameters in psoriasis patients and healthy controls. METHODS: Forty-six patients with psoriasis and 43 healthy controls were included. The severity of the disease was assessed with Psoriasis Area Severity Index (PASI) in the patient group. Levels of SCUBE-1, CRP, lipids, and fasting glucose were measured with the enzyme-linked ımmunosorbent assay (ELISA) method, and CIMT measurements were performed by the same cardiologist. RESULTS: SCUBE-1 levels and CIMT values were significantly higher in the patient group (for both p < 0.05). Moreover, systolic blood pressure, CRP levels, and waist circumference were higher in the patient group even though both groups had similar BMIs (for all p < 0.05). A positive correlation was found between SCUBE-1 and CIMT values among patients, and multiple regression analyses revealed that SCUBE-1 and CIMT are significantly associated with psoriasis as well. STUDY LIMITATIONS: A low number of participants and not including any other inflammatory marker related to angiogenesis or atherosclerosis such as VEGF, adiponectin are the main limitations of the present study. CONCLUSION: Despite the severity of the disease, even in psoriasis patients with mild disease the SCUBE-1 level may be an indicator of subclinical atherosclerosis and indicate the risk of cardiovascular disease in the future. |
format | Online Article Text |
id | pubmed-10404550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-104045502023-08-08 Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?() Ayvaz Çelik, Havva Hilal Kuyumcu, Mevlüt Serdar Şirin, Fevziye Burcu Cirit, Mehmet Korkmaz, Selma Erturan, İjlal Çelik, Seda Yıldırım, Mehmet An Bras Dermatol Original Article BACKGROUND: Psoriasis is a chronic inflammatory disease that is associated with many inflammatory conditions such as atherosclerosis, hypertension, among others. SCUBE-1 is a protein that plays a role in angiogenesis. OBJECTIVES: The present study aimed to investigate whether SCUBE-1 could indicate subclinical atherosclerosis in psoriatic patients, and to compare SCUBE-1 levels, measurement of carotid artery ıntima-media thickness (CIMT), and metabolic parameters in psoriasis patients and healthy controls. METHODS: Forty-six patients with psoriasis and 43 healthy controls were included. The severity of the disease was assessed with Psoriasis Area Severity Index (PASI) in the patient group. Levels of SCUBE-1, CRP, lipids, and fasting glucose were measured with the enzyme-linked ımmunosorbent assay (ELISA) method, and CIMT measurements were performed by the same cardiologist. RESULTS: SCUBE-1 levels and CIMT values were significantly higher in the patient group (for both p < 0.05). Moreover, systolic blood pressure, CRP levels, and waist circumference were higher in the patient group even though both groups had similar BMIs (for all p < 0.05). A positive correlation was found between SCUBE-1 and CIMT values among patients, and multiple regression analyses revealed that SCUBE-1 and CIMT are significantly associated with psoriasis as well. STUDY LIMITATIONS: A low number of participants and not including any other inflammatory marker related to angiogenesis or atherosclerosis such as VEGF, adiponectin are the main limitations of the present study. CONCLUSION: Despite the severity of the disease, even in psoriasis patients with mild disease the SCUBE-1 level may be an indicator of subclinical atherosclerosis and indicate the risk of cardiovascular disease in the future. Sociedade Brasileira de Dermatologia 2023 2023-05-15 /pmc/articles/PMC10404550/ /pubmed/37198010 http://dx.doi.org/10.1016/j.abd.2022.08.012 Text en © 2023 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Ayvaz Çelik, Havva Hilal Kuyumcu, Mevlüt Serdar Şirin, Fevziye Burcu Cirit, Mehmet Korkmaz, Selma Erturan, İjlal Çelik, Seda Yıldırım, Mehmet Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?() |
title | Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?() |
title_full | Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?() |
title_fullStr | Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?() |
title_full_unstemmed | Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?() |
title_short | Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?() |
title_sort | could scube-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?() |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404550/ https://www.ncbi.nlm.nih.gov/pubmed/37198010 http://dx.doi.org/10.1016/j.abd.2022.08.012 |
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