Patient-Induced Pluripotent Stem Cell–Derived Hepatostellate Organoids Establish a Basis for Liver Pathologies in Telomeropathies

BACKGROUND & AIMS: Dyskeratosis congenita (DC) is a telomere biology disorder caused primarily by mutations in the DKC1 gene. Patients with DC and related telomeropathies resulting from premature telomere dysfunction experience multiorgan failure. In the liver, DC patients present with nodular h...

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Detalles Bibliográficos
Autores principales: Choi, Young-Jun, Kim, Melissa S., Rhoades, Joshua H., Johnson, Nicolette M., Berry, Corbett T., Root, Sarah, Chen, Qijun, Tian, Yuhua, Fernandez, Rafael J., Cramer, Zvi, Adams-Tzivelekidis, Stephanie, Li, Ning, Johnson, F. Brad, Lengner, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404563/
https://www.ncbi.nlm.nih.gov/pubmed/37302654
http://dx.doi.org/10.1016/j.jcmgh.2023.06.003

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