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Lipidated variants of the antimicrobial peptide nisin produced via incorporation of methionine analogs for click chemistry show improved bioactivity

The increase in antibiotic resistance calls for accelerated molecular engineering strategies to diversify natural products for drug discovery. The incorporation of non-canonical amino acids (ncAAs) is an elegant strategy for this purpose, offering a diverse pool of building blocks to introduce desir...

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Detalles Bibliográficos
Autores principales:	Guo, Longcheng, Wang, Chenhui, Broos, Jaap, Kuipers, Oscar P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404616/ https://www.ncbi.nlm.nih.gov/pubmed/37209826 http://dx.doi.org/10.1016/j.jbc.2023.104845

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