The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells

Neuroblastoma (NB) is one of the most common extracranial solid tumors in children. MYCN gene amplification is highly associated with poor prognosis in high-risk NB patients. In non-MYCN-amplified high-risk NB patients, the expression of c-MYC (MYCC) and its target genes is highly elevated. USP28 as...

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Detalles Bibliográficos
Autores principales: Li, Junjun, Peng, Jin, Wu, Lingzhi, Shen, Xiang, Zhen, Xinghua, Zhang, Yimao, Ma, Huailu, Xu, Yongfeng, Xiong, Qunli, Zhu, Qing, Zhang, Pumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404617/
https://www.ncbi.nlm.nih.gov/pubmed/37230388
http://dx.doi.org/10.1016/j.jbc.2023.104856

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