Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis but facilitates termination of emergency (stress) granulopoiesis

Age-associated bone marrow changes include myeloid skewing and mutations that lead to clonal hematopoiesis. Molecular mechanisms for these events are ill defined, but decreased expression of Irf8/Icsbp (interferon regulatory factor 8/interferon consensus sequence binding protein) in aging hematopoie...

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Detalles Bibliográficos
Autores principales: Williams, Olatundun, Hu, Liping, Huang, Weiqi, Patel, Priyam, Bartom, Elizabeth T., Bei, Ling, Hjort, Elizabeth, Hijiya, Christina, Eklund, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404618/
https://www.ncbi.nlm.nih.gov/pubmed/37247756
http://dx.doi.org/10.1016/j.jbc.2023.104867

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