The U1 antisense morpholino oligonucleotide (AMO) disrupts U1 snRNP structure to promote intronic PCPA modification of pre-mRNAs

Functional depletion of the U1 small nuclear ribonucleoprotein (snRNP) with a 25 nt U1 AMO (antisense morpholino oligonucleotide) may lead to intronic premature cleavage and polyadenylation of thousands of genes, a phenomenon known as U1 snRNP telescripting; however, the underlying mechanism remains...

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Detalles Bibliográficos
Autores principales: Feng, Qiumin, Lin, Zejin, Deng, Yanhui, Ran, Yi, Yu, Rui, Xiang, Andy Peng, Ye, Congting, Yao, Chengguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
JBC Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404622/
https://www.ncbi.nlm.nih.gov/pubmed/37224962
http://dx.doi.org/10.1016/j.jbc.2023.104854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404622/
https://www.ncbi.nlm.nih.gov/pubmed/37224962
http://dx.doi.org/10.1016/j.jbc.2023.104854

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