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Structure of complex III with bound antimalarial agent CK-2-68 provides insights into selective inhibition of Plasmodium cytochrome bc(1) complexes

Among the various components of the protozoan Plasmodium mitochondrial respiratory chain, only Complex III is a validated cellular target for antimalarial drugs. The compound CK-2-68 was developed to specifically target the alternate NADH dehydrogenase of the malaria parasite respiratory chain, but...

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Detalles Bibliográficos
Autores principales:	Esser, Lothar, Zhou, Fei, Zeher, Allison, Wu, Weimin, Huang, Rick, Yu, Chang-An, Lane, Kristin D., Wellems, Thomas E., Xia, Di
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404626/ https://www.ncbi.nlm.nih.gov/pubmed/37236355 http://dx.doi.org/10.1016/j.jbc.2023.104860

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