Dissecting the contributions of membrane affinity and bivalency of the spider venom protein DkTx to its sustained mode of TRPV1 activation

The spider venom protein, double-knot toxin (DkTx), partitions into the cellular membrane and binds bivalently to the pain-sensing ion channel, TRPV1, triggering long-lasting channel activation. In contrast, its monovalent single knots membrane partition poorly and invoke rapidly reversible TRPV1 ac...

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Detalles Bibliográficos
Autores principales: Singh, Yashaswi, Sarkar, Debayan, Duari, Subhadeep, G, Shashaank, Indra Guru, Pawas Kumar, M V, Hrishikesh, Singh, Dheerendra, Bhardwaj, Sahil, Kalia, Jeet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404664/
https://www.ncbi.nlm.nih.gov/pubmed/37302551
http://dx.doi.org/10.1016/j.jbc.2023.104903

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