Src stimulates Abl-dependent phosphorylation of the guanine exchange factor Net1A to promote its cytosolic localization and cell motility

The neuroepithelial cell transforming gene 1 (Net1) is a guanine nucleotide exchange factor for the small GTPase RhoA that promotes cancer cell motility and metastasis. Two isoforms of Net1 exist, Net1 and Net1A, both of which are sequestered in the nucleus in quiescent cells to prevent aberrant Rho...

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Detalles Bibliográficos
Autores principales: Sprenger, Ashabari, Carr, Heather S., Ulu, Arzu, Frost, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404680/
https://www.ncbi.nlm.nih.gov/pubmed/37271338
http://dx.doi.org/10.1016/j.jbc.2023.104887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404680/
https://www.ncbi.nlm.nih.gov/pubmed/37271338
http://dx.doi.org/10.1016/j.jbc.2023.104887

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