A biosynthetic aspartate N-hydroxylase performs successive oxidations by holding intermediates at a site away from the catalytic center

Nitrosuccinate is a biosynthetic building block in many microbial pathways. The metabolite is produced by dedicated L-aspartate hydroxylases that use NADPH and molecular oxygen as co-substrates. Here, we investigate the mechanism underlying the unusual ability of these enzymes to perform successive...

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Detalles Bibliográficos
Autores principales: Rotilio, Laura, Boverio, Alessandro, Nguyen, Quoc-Thai, Mannucci, Barbara, Fraaije, Marco W., Mattevi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404684/
https://www.ncbi.nlm.nih.gov/pubmed/37302552
http://dx.doi.org/10.1016/j.jbc.2023.104904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404684/
https://www.ncbi.nlm.nih.gov/pubmed/37302552
http://dx.doi.org/10.1016/j.jbc.2023.104904

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