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SAMHD1 impairs type I interferon induction through the MAVS, IKKε, and IRF7 signaling axis during viral infection

Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) restricts human immunodeficiency virus type 1 (HIV-1) infection by reducing the intracellular dNTP pool. We have shown that SAMHD1 suppresses nuclear factor kappa-B activation and type I interferon (IFN-I) induction by viral infection a...

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Detalles Bibliográficos
Autores principales:	Espada, Constanza E., Sari, Levent, Cahill, Michael P., Yang, Hua, Phillips, Stacia, Martinez, Nicholas, Kenney, Adam D., Yount, Jacob S., Xiong, Yong, Lin, Milo M., Wu, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404699/ https://www.ncbi.nlm.nih.gov/pubmed/37328105 http://dx.doi.org/10.1016/j.jbc.2023.104925

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