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The distinct initiation sites and processing activities of TTLL4 and TTLL7 in glutamylation of brain tubulin

Mammalian brain tubulins undergo a reversible posttranslational modification—polyglutamylation—which attaches a secondary polyglutamate chain to the primary sequence of proteins. Loss of its erasers can disrupt polyglutamylation homeostasis and cause neurodegeneration. Tubulin tyrosine ligase like 4...

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Detalles Bibliográficos
Autores principales:	Zhang, Xinyue, Li, Xiangxiao, Chen, Wei, Wang, Yujuan, Diao, Lei, Gao, Yan, Wang, Heyi, Bao, Lan, Liang, Xin, Wu, Hui-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404701/ https://www.ncbi.nlm.nih.gov/pubmed/37321451 http://dx.doi.org/10.1016/j.jbc.2023.104923

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