The effect of C(60) fullerene on the mechanokinetics of muscle gastrocnemius contraction in chronically alcoholized rats

The C(60) fullerene effect (oral administration at a dose of 1 mg kg(−1)) on the selected biomechanical parameters of muscle gastrocnemius contraction, biochemical indicators of blood and muscle tissue as well as histological changes in rat muscle tissue after chronic alcoholization for 3, 6 and 9 months was studied in detail. Water-soluble C(60) fullerenes were shown to reduce the pathological processes development in the muscle apparatus by an average of (35–40)%. In particular, they reduced the time occurrence of fatigue processes in muscle during the long-term development of alcoholic myopathy and inhibited oxidative processes in muscle, thereby preventing its degradation. These findings open up the possibility of using C(60) fullerenes as potent antioxidants for the correction of the pathological conditions of the muscle system arising from alcohol intoxication.