What does not look like celiac disease and instead it is

The celiac disease (CD) diagnosis sometimes is challenging and diagnostic process cannot always follow a simple algorithm but it requires a close collaboration between histo-pathologists, clinicians, laboratory and genetic experts. The genetic predisposition for CD is related to HLA-DQ2 and/or DQ8 b...

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Autores principales: Villanacci, Vincenzo, Del Sordo, Rachele, Setti, Orsola, Zanini, Barbara, Casella, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404839/
https://www.ncbi.nlm.nih.gov/pubmed/37554742
http://dx.doi.org/10.22037/ghfbb.v16i1.2686
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author Villanacci, Vincenzo
Del Sordo, Rachele
Setti, Orsola
Zanini, Barbara
Casella, Giovanni
author_facet Villanacci, Vincenzo
Del Sordo, Rachele
Setti, Orsola
Zanini, Barbara
Casella, Giovanni
author_sort Villanacci, Vincenzo
collection PubMed
description The celiac disease (CD) diagnosis sometimes is challenging and diagnostic process cannot always follow a simple algorithm but it requires a close collaboration between histo-pathologists, clinicians, laboratory and genetic experts. The genetic predisposition for CD is related to HLA-DQ2 and/or DQ8 but other HLA haplotypes and non-HLA genes may be involved in genetic predisposition. In particular DQ7 may represent an additive and independent CD risk associated haplotype. We describe an unusual case of a female 42 year old with a previous diagnosis of Hodgkin lymphoma, who has a clinical presentation suggestive for CD with negativity for anti-transglutaminase and anti-endomysium antibodies and HLA-DQ7 positivity.
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spelling pubmed-104048392023-08-08 What does not look like celiac disease and instead it is Villanacci, Vincenzo Del Sordo, Rachele Setti, Orsola Zanini, Barbara Casella, Giovanni Gastroenterol Hepatol Bed Bench Case Report The celiac disease (CD) diagnosis sometimes is challenging and diagnostic process cannot always follow a simple algorithm but it requires a close collaboration between histo-pathologists, clinicians, laboratory and genetic experts. The genetic predisposition for CD is related to HLA-DQ2 and/or DQ8 but other HLA haplotypes and non-HLA genes may be involved in genetic predisposition. In particular DQ7 may represent an additive and independent CD risk associated haplotype. We describe an unusual case of a female 42 year old with a previous diagnosis of Hodgkin lymphoma, who has a clinical presentation suggestive for CD with negativity for anti-transglutaminase and anti-endomysium antibodies and HLA-DQ7 positivity. Shaheed Beheshti University of Medical Sciences 2023 /pmc/articles/PMC10404839/ /pubmed/37554742 http://dx.doi.org/10.22037/ghfbb.v16i1.2686 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/) which permits others to copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Case Report
Villanacci, Vincenzo
Del Sordo, Rachele
Setti, Orsola
Zanini, Barbara
Casella, Giovanni
What does not look like celiac disease and instead it is
title What does not look like celiac disease and instead it is
title_full What does not look like celiac disease and instead it is
title_fullStr What does not look like celiac disease and instead it is
title_full_unstemmed What does not look like celiac disease and instead it is
title_short What does not look like celiac disease and instead it is
title_sort what does not look like celiac disease and instead it is
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404839/
https://www.ncbi.nlm.nih.gov/pubmed/37554742
http://dx.doi.org/10.22037/ghfbb.v16i1.2686
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