Late relapsing testicular cancer detected with 18F-FDG PET preceded by long-term alpha-fetoprotein elevation

Late relapse (LR) of testicular cancer is often associated with chemoresistance, and thus the first choice of therapy is surgery if complete resection is possible. In some LR cases (including our patient, a 31-year-old Japanese man), elevation of alpha-fetoprotein (AFP) may precede the radiologic de...

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Detalles Bibliográficos
Autores principales: Sakurai, Hiromichi, Katami, Akinobu, Yuki, Hiroshi, Matsuoka, Ryosuke, Kawai, Koji, Shiomi, Takayuki, Miyazaki, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404854/
https://www.ncbi.nlm.nih.gov/pubmed/37554669
http://dx.doi.org/10.1016/j.eucr.2023.102511
Descripción
Sumario:Late relapse (LR) of testicular cancer is often associated with chemoresistance, and thus the first choice of therapy is surgery if complete resection is possible. In some LR cases (including our patient, a 31-year-old Japanese man), elevation of alpha-fetoprotein (AFP) may precede the radiologic detection of LR. Approximately 500 days after the start of our patient's AFP elevation, 18F-fluordeoxyglucose positron emission tomography (FDG-PET) revealed strong FDG uptake in an equivocally enlarged external iliac lymph node. The lymphadenectomy as salvage surgery resulted in long-term complete remission without further treatment. Using FDG-PET made it possible to perform effective salvage surgery.

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