Late relapsing testicular cancer detected with 18F-FDG PET preceded by long-term alpha-fetoprotein elevation

Late relapse (LR) of testicular cancer is often associated with chemoresistance, and thus the first choice of therapy is surgery if complete resection is possible. In some LR cases (including our patient, a 31-year-old Japanese man), elevation of alpha-fetoprotein (AFP) may precede the radiologic de...

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Autores principales: Sakurai, Hiromichi, Katami, Akinobu, Yuki, Hiroshi, Matsuoka, Ryosuke, Kawai, Koji, Shiomi, Takayuki, Miyazaki, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404854/
https://www.ncbi.nlm.nih.gov/pubmed/37554669
http://dx.doi.org/10.1016/j.eucr.2023.102511
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author Sakurai, Hiromichi
Katami, Akinobu
Yuki, Hiroshi
Matsuoka, Ryosuke
Kawai, Koji
Shiomi, Takayuki
Miyazaki, Jun
author_facet Sakurai, Hiromichi
Katami, Akinobu
Yuki, Hiroshi
Matsuoka, Ryosuke
Kawai, Koji
Shiomi, Takayuki
Miyazaki, Jun
author_sort Sakurai, Hiromichi
collection PubMed
description Late relapse (LR) of testicular cancer is often associated with chemoresistance, and thus the first choice of therapy is surgery if complete resection is possible. In some LR cases (including our patient, a 31-year-old Japanese man), elevation of alpha-fetoprotein (AFP) may precede the radiologic detection of LR. Approximately 500 days after the start of our patient's AFP elevation, 18F-fluordeoxyglucose positron emission tomography (FDG-PET) revealed strong FDG uptake in an equivocally enlarged external iliac lymph node. The lymphadenectomy as salvage surgery resulted in long-term complete remission without further treatment. Using FDG-PET made it possible to perform effective salvage surgery.
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spelling pubmed-104048542023-08-08 Late relapsing testicular cancer detected with 18F-FDG PET preceded by long-term alpha-fetoprotein elevation Sakurai, Hiromichi Katami, Akinobu Yuki, Hiroshi Matsuoka, Ryosuke Kawai, Koji Shiomi, Takayuki Miyazaki, Jun Urol Case Rep Oncology Late relapse (LR) of testicular cancer is often associated with chemoresistance, and thus the first choice of therapy is surgery if complete resection is possible. In some LR cases (including our patient, a 31-year-old Japanese man), elevation of alpha-fetoprotein (AFP) may precede the radiologic detection of LR. Approximately 500 days after the start of our patient's AFP elevation, 18F-fluordeoxyglucose positron emission tomography (FDG-PET) revealed strong FDG uptake in an equivocally enlarged external iliac lymph node. The lymphadenectomy as salvage surgery resulted in long-term complete remission without further treatment. Using FDG-PET made it possible to perform effective salvage surgery. Elsevier 2023-07-22 /pmc/articles/PMC10404854/ /pubmed/37554669 http://dx.doi.org/10.1016/j.eucr.2023.102511 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Sakurai, Hiromichi
Katami, Akinobu
Yuki, Hiroshi
Matsuoka, Ryosuke
Kawai, Koji
Shiomi, Takayuki
Miyazaki, Jun
Late relapsing testicular cancer detected with 18F-FDG PET preceded by long-term alpha-fetoprotein elevation
title Late relapsing testicular cancer detected with 18F-FDG PET preceded by long-term alpha-fetoprotein elevation
title_full Late relapsing testicular cancer detected with 18F-FDG PET preceded by long-term alpha-fetoprotein elevation
title_fullStr Late relapsing testicular cancer detected with 18F-FDG PET preceded by long-term alpha-fetoprotein elevation
title_full_unstemmed Late relapsing testicular cancer detected with 18F-FDG PET preceded by long-term alpha-fetoprotein elevation
title_short Late relapsing testicular cancer detected with 18F-FDG PET preceded by long-term alpha-fetoprotein elevation
title_sort late relapsing testicular cancer detected with 18f-fdg pet preceded by long-term alpha-fetoprotein elevation
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404854/
https://www.ncbi.nlm.nih.gov/pubmed/37554669
http://dx.doi.org/10.1016/j.eucr.2023.102511
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