Defective EMC1 drives abnormal retinal angiogenesis via Wnt/β-catenin signaling and may be associated with the pathogenesis of familial exudative vitreoretinopathy

Endoplasmic reticulum (ER) membrane protein complex (EMC) is required for the co-translational insertion of newly synthesized multi-transmembrane proteins. Compromised EMC function in different cell types has been implicated in multiple diseases. Using inducible genetic mouse models, we revealed def...

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Detalles Bibliográficos
Autores principales: Li, Shujin, Yang, Mu, Zhao, Rulian, Peng, Li, Liu, Wenjing, Jiang, Xiaoyan, He, Yunqi, Dai, Erkuan, Zhang, Lin, Yang, Yeming, Shi, Yi, Zhao, Peiquan, Yang, Zhenglin, Zhu, Xianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2022
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404869/
https://www.ncbi.nlm.nih.gov/pubmed/37554197
http://dx.doi.org/10.1016/j.gendis.2022.10.003

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